CONNECTIONS BETWEEN OBESITY AND COLORECTAL CANCER. THE ROLE OF INFLAMMATION MEDIATED BY GHRELIN AXIS IN THE ADIPOSE TISSUE
CONNECTIONS BETWEEN OBESITY AND COLORECTAL CANCER. THE ROLE OF INFLAMMATION MEDIATED BY GHRELIN AXIS IN ADIPOSE TISSUE (Abstract): Obesity and colorectal cancer are two major global health issues. Although they seem to lack a clear connection, epidemiologic analysis found a significant association. This led to further evaluation and identification of molecular pathways that stand at the basis of these findings. One of them is chronic inflammation, a state associated with obesity and colorectal cancer. Adipose tissue from obese individuals suffers a pathogenic switch responsible for higher inflammatory capacity. This modulates the interplay between inflammation and colorectal cancer cells. Through growth factors and cytokines, adipose tissue creates a favorable microenvironment for tumor development. Our focus is on the ghrelin-growth hormone secretagogue receptor axis which promotes inflammation and has mitogenic and antiapoptotic capacity on cancer cells, acting through various mechanisms including via TNF-α which promotes tumor cell proliferation, growth and metastasis and IL-6, a molecule associated with tumor size and stage in colorectal cancer patients.
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