POSSIBLE RELEVANCE OF PHYSICAL EXERCISING IN ALZHEIMER’S DISEASE AND OTHER DEMENTIAS

  • A. CIOBICA Alexandru Ioan Cuza” University, Iasi, Romania
  • C. HONCERIU Alexandru Ioan Cuza” University, Iasi, Romania
  • Al. CIOBICA Academy of Romanian Scientists, Bucuresti, Romania
  • D. COJOCARU “Alexandru Ioan Cuza” University, Iasi, Romania
  • F. TROFIN “Alexandru Ioan Cuza” University, Iasi, Romania
  • R. DOBRIN “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Ioana Miruna BALMUS “Alexandru Ioan Cuza” University, Iasi, Romania
  • D. V. TIMOFTE “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Abstract

POSSIBLE RELEVANCE OF PHYSICAL EXERCISING IN ALZHEIMER’S DISEASE AND OTHER DEMENTIAS (Abstract): The benefits of consistent exercising, either cardiovascular, strength training or a combination of both, have been recently shown in neuropsychiatric patients such as Alzheimer’s disease and other dementia cases. In this way, an inverse relationship between cognitive impairment commonly observed in demented patients and cardiovascular fitness was demonstrated in a multitude of recent studies, which will be described and analyzed here. Moreover, several related features such as the relevance of oxidative stress, obesity and inflammation are discussed in this context. In addition, intensive muscle training was shown to be particularly effective leading to improved postural and motor response, and therefore reducing the motor impairments effects in dementia patients. Thus, the current trend in prevention is to support physical activity to delay dementia onset, knowing that physical exercising may be crucial in slowing or stopping the motor and general abilities decline in these patients.

Author Biographies

Al. CIOBICA, Academy of Romanian Scientists, Bucuresti, Romania

Department of Research, Faculty of Biology, Iasi, Romania
Center of Biomedical Research, Romanian Academy, Iasi, Romania

D. COJOCARU, “Alexandru Ioan Cuza” University, Iasi, Romania

Academy of Romanian Scientists, Bucuresti, Romania

References

1. Perrin R, Fagan A, David M. Multi-modal techniques for diagnosis and prognosis of Alzheimer's disease. Nature 2009; 461: 916-922.
2. Padurariu M, Ciobica A, Hritcu L, Stoica B, Bild W, Stefanescu C. Changes of some oxidative stress markers in the serum of patients with mild cognitive impairment and Alzheimer's disease. Neurosci Lett 2010; 469: 6-10.
3. Tang W, Olscamp K, Choi SK, Friedman DB. Alzheimer's Disease in Social Media: Content Analysis of YouTube Videos. Interact J Med Res. 2017; 6(2): e19.
4. Topolovec-Vranic J, Natarajan K. The Use of Social Media in Recruitment for Medical Research Studies: A Scoping Review. Eysenbach G (ed). Journal of Medical Internet Research 2016; 18(11): e286.
5. Luca FA, Filipeanu D, Anton C, Cananau M, Luca AC, Anton E. The Impact of Patterns Provided by the Media on Society. Revista de Cercetare si Interventie Sociala 2016; 52: 204-216.
6. Selkoe D. Alzheimer's disease: genes, proteins, and therapy. Physiological Reviews 2001; 81: 741-766.
7. Kramer AF, Erickson KI, Colcombe SJ. Exercise, cognition, and the aging brain. J Appl Physiol 2006; 101: 1237-1242.
8. Burns JM, Cronk BB, Anderson HS, Donnelly JE, Thomas GP, Harsha A, Brooks WM, Swerdlow RH. Cardiorespiratory fitness and brain atrophy in early Alzheimer disease. Neurology 2008; 71: 210-216.
9. Lautenschlager NT, Cox, KL, Flicker L. Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial. JAMA 2008; 300: 1027-1037.
10. Baker LD, Frank LL, Foster-Schubert K. Effects of aerobic exercise on mild cognitive impairment: a controlled trial. Arch Neurol 2010; 67: 71-79.
11. Sandu E, Ciobica A, Oprica L, Anton E, Timofte D. The relevance body mass index on the oxidative stress status of Alzheimer’s disease pathology, Analele Ştiinţifice ale Universităţii „Alexandru Ioan Cuza”, Secţiunea Genetică şi Biologie Moleculară 2014; 15: 9-18.
12. Padurariu M, Ciobica A, Lefter R, Serban, IL, Stefanescu C, Chirita R. The oxidative stress hypothesis in Alzheimer's disease. Psychiatr Danub 2013; 25: 401-409.
13. Flicker, L. Life style interventions to reduce the risk of dementia. Maturitas 2009; 63: 319-322.
14. Rovio S, Spulber G, Nieminen L. The effect of midlife physical activity on structural brain changes in the elderly. Neurobiol Aging 2010; 31; 1927-1936.
15. Colcombe S, Kramer AF. Fitness effects on the cognitive function of older adults: a meta-analytic study. Psychol Sci 2003; 14: 125-130.
16. Burns JM, Mayo MS, Anderson HS, Smith HJ, Donnelly JE. Cardiorespiratory fitness in early-stage Alzheimer disease. Alzheimer Dis Assoc Disord 2008; 22: 39-46.
17. Middleton LE, Barnes DE, Li-Yung Lui MS, Kristine Yaffe K. Physical Activity Over the Life Course and its Association with Cognitive Performance and Impairment in Old Age. J Am Geriatr Soc 2010; 58(7): 1322-1326.
18. Qin L, Liu Y, Cooper C, Liu B, Wilson B, Hong J. Microglia enhance beta-amyloid peptide induced toxicity in cortical and mesencephalic neurons by producing reactive oxygen species. Journal of Neu-rochemistry 2002; 83: 973-983.
19. Butterfield D, Drake J, Pocernich C, Castegna A. Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide. Trends in Molecular Medicine 2001; 7: 548-554.
20. Khan N, Naz L, Yasmeen G. Obesity An independent risk factor systemic oxidative stress. Park. J. Pharm. Sci 2006; 19: 62-69.
21. Trofin F, Honceriu C, Ciobica A, Cojocaru D. The Influence of Vitamin C on the Oxidative Stress in Untrained Smoking Subjects. Applied Mechanics and Materials 2014; 555: 713-722.
22. Trofin F, Chirazi M, Honceriu C, Drosescu P, Grădinariu G, Vorniceanu A. Pre-administration of vitamin C reduces exercise-induced oxidative stress status in untrained subjects. Archives of Biological Sciences Belgr 2014; 66: 1179-1185.
23. Trofin F, Ciobica A, Cojocaru D, Chirazi M, Honceriu C, Trofin L. Increased oxidative stress in rat after five minutes treadmill exercise. Central European Journal of Medicine 2014; 9: 722-728.
24. Kuźbicka K, Rachoń D. Bad eating habits as the main cause of obesity among children. Pediatr En-docrinol Diabetes Metab 2003; 19: 106-110.
25. Sentürk UK, Gündüz F, Kuru O, Aktekin MR, Kipmen D, Yalçin O. Exercise-induced oxidative stress affects erythrocytes in sedentary rats but not exercise-trained rats. J Appl Physiol 2001; 91: 1999-2004.
26. Ancuţa C, Pomîrleanu DC, Anton CR, Moraru E, Anton E, Chirieac RM, Ancuţa E. Rheumatoid myositis, myth or reality? A clinical, imaging and histological study. Rom J Morphol Embryol 2014; 55(3): 781-785.
27. Ancuta C, Ancuta E, Chirieac R, Anton C, Surlari Z, Iordache C. TNF inhibitors and periodontal inflammation in psoriatic arthritis, Rev.Chim. (Bucharest) 2017; 68(8): 1914-1918.
28. Policicchio S, Ahmad AN, Powell JF, Proitsi P. Rheumatoid arthritis and risk for Alzheimer's disease: a systematic review and meta-analysis and a Mendelian Randomization study. Sci Rep 2017; 7(1): 12861.
29. Fuggle NR, Howe FA, Allen RL, Sofat N. New insights into the impact of neuro-inflammation in rheumatoid arthritis. Frontiers in Neuroscience 2014; 8: 357.
30. Roos PM, Vesterberg O, Nordberg M. Inclusion body myositis in Alzheimer's disease. Acta Neurol Scand 2011; 124(3): 215-217.
31. Levacic D, Peddareddygari LR, Nochlin D, Sharer LR, Grewal RP. Inclusion-body myositis associated with Alzheimer's disease. Case Rep Med 2013; 2013: 536231.
32. Hurley BF, Hanson ED, Sheaff AK. Strength training as a countermeasure to aging muscle and chronic disease. Sports Med 2011; 41: 289-306.
33. Hill KD, LoGiudice D, Lautenschlager NT, Said CM, Dodd J, Suttanon P. Effectiveness of balance training exercise in people with mild to moderate severity Alzheimer's disease: protocol for a random-ized trial. BMC Geriatr 2009; 9: 29.
34. Suttanon P, Hill KD, Said CM, William SB, Byrne KN, LoGiudice D. Feasibility, safety and prelimi-nary evidence of the effectiveness of a home-based exercise programme for older people with Alz-heimer's disease: a pilot randomized controlled trial. Clin Rehabil 2013; 27: 427-438.
35. Rolland Y, Pillard F, Klapouszczak A. Exercise program for nursing home residents with Alzheimer’s disease: a 1-year randomized, controlled trial. J Am Geriatr Soc 2007; 55: 158-165.
36. Hernandez SS, Coelho FG, Gobbi S, Stella F. Effects of physical activity on cognitive functions, balance and risk of falls in elderly patients with Alzheimer’s dementia. Rev Bras Fisioter 2010; 14: 68-74.
37. Petrella JK, Miller LS, Cress ME. Leg extensor power, cognition, and functional performance in independent and marginally dependent older adults. Age Ageing 2004; 33: 342-348.
38. Scherder EJ, Eggermont LH, Geuze RH, Vis J, Verkerk GJ. Quadriceps strength and executive func-tions in older women. Am J Phys Med Rehabil 2010; 89: 458-463.
39. Cassilhas RC, Vian VA, Grassmann V. The impact of resistance exercise on the cognitive function of the elderly. Med Sci Sports Exerc 2007; 39: 1401-1407.
40. Liu-Ambrose T, Nagamats LS, Graf P, Beattie BL, Ashe MC, Handy TC. Resistance training and executive functions: a 12-month randomized controlled trial. Arch Intern Med 2010; 170: 170-178.
41. Nagamatsu LS, Handy T, Liang H, Voss M, Liu-Ambrose T. Resistance training promotes cognitive and functional brain plasticity in seniors with probable mild cognitive impairment: A 6-month ran-domized controlled trial. Arch Intern Med 2012; 172: 666-668.
42. Boyle PA, Buchman AS, Wilson RS, Sue E. Association of Muscle Strength with the Risk of Alz-heimer’s Disease and the Rate of Cognitive Decline in Community-Dwelling Older Persons. Arch Neurol 2009; 66: 1339-1344.
43. Alexa ID, Ilie CA, Morosanu A, Papaioannou Emmanouil-Stamos, Ismo Räihä. Self-neglect in elders: a worldwide issue ignored in Romania. Revista Romana de Bioetica 2012; 12(3): 141-148.
44. Cepoi V, Alexa ID, Ilie CA, Alexa O. Ethical dilemmas in treating elderly patients at risk of poly-pragmasy and polypharmacy. Revista Romana de Bioetica 2014; 12(3): 12-18.
45. Rodriguez G, De Leo C, Girtler N, Vitali P, Grossi E, Nobili F. Psychological and social aspects in management of Alzheimer's patients: an inquiry among caregivers. Neurol Sci 2003; 24(5): 329-335.
46. Mårdh S, Karlsson T, Marcusson J. Aspects of awareness in patients with Alzheimer's disease. Int Psychogeriatr 2013; 25(7): 1167-1179.
47. Davis JC, Hsiung GY, Liu-Ambrose T. Challenges moving forward with economic evaluations of exercise intervention strategies aimed at combating cognitive impairment and dementia. Br J Sports Med 2011; 45: 470-472.
Published
2018-10-02
Section
INTERNAL MEDICINE - PEDIATRICS