CLINICOPATHOLOGICAL FEATURES OF JUVENILE GRANULOSA CELL TUMOR WITH AN EXTENSIVE MUCINOUS COMPONENT. CASE REPORT
CLINICOPATHOLOGICAL FEATURES OF JUVENILE GRANULOSA CELL TUMOR WITH AN EXTENSIVE MUCINOUS COMPONENT. CASE REPORT (Abstract): Granulosa cell tumors (GCTs) are a rare type of ovarian neoplasm accounting for only 2-3% and their mix with mucinous elements is uncommon. Despite their favorable natural course, correct diagnosis is imperative for proper management to prevent metastatic spread and local recurrences. We herein report a case of a 34-year-old female patient presenting to our clinic with a pelvic mass which required surgical removal. Her past medical history was peculiar: she was diagnosed with a right ovarian tumor for which she underwent total hysterectomy with bilateral salpingo-oophorectomy. Histological features of the specimen suggested the diagnosis of mucinous ovarian carcinoma. Seven years later, she underwent a right hemicolectomy for a tumor recurrence involving the ascending colon, followed by the same histological diagnosis. After another eight years, a computed tomography scan showed a pelvic tumor which was removed and after histological evaluation with extensive immunohistochemical staining the diagnosis was clarified: juvenile granulosa cell tumor with extensive mucinous component. Our case report emphasizes the necessity of immunohistochemical staining for accurate diagnosis, especially when clinical features do not correlate with histology findings. Moreover, due to the rarity of these types of tumors, further reports and studies are encouraged to standardize their diagnosis and treatment.
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