HEPATOTOXICITY – CURRENT CONCEPTS AND MECHANISMS

  • Nicoleta-Loredana HILITANU Rehabilitation Clinical Hospital, Iasi
  • Liliana MITITELU-TARTAU “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Paraschiva POSTOLACHE “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • F. D. PETRARIU “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Veronica OPREA “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Abstract

HEPATOTOXICITY-CURRENT CONCEPTS AND MECHANISMS (Abstract): Liver is the main organ with critical metabolic functions, contributing to the biotransformation of numerous molecules. It has an essential role in converting and clearing of active agents and it is extremely vulnerable to the toxins. The use of chemicals (drugs, abuse substances, poisons, industrial and occupational agents, herbal remedies and dietary supplements) is an important cause of hepatic cells damages, most of them being involved in the development of liver injury. Three types of mechanisms may be responsible for the occurrence of liver toxicity: overdose, drug allergy and idiosyncratic reaction. This review aims to highlight the category of chemicals responsible for the architecture damage and liver function disturbances. The influence of various agents on the liver function may be accompanied by a multitude of manifestations, represented by the increase in liver enzymes activity, hepatocytolysis or liver failure. It is very important to recognize the commonly involved compounds, identify their adverse effects, especially during the drug associations, identify their mechanisms of action, predict and limit their harmful effects in contact with the body. Considering the clinical repercussions of chemical-mediated liver injuries, this review brings into attention several potential hepatotoxic compounds and their pathophysiological mechanisms.

Author Biographies

Nicoleta-Loredana HILITANU, Rehabilitation Clinical Hospital, Iasi

Clinic of Occupational Medicine

Liliana MITITELU-TARTAU, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Faculty of Medicine
Department of Morpho-Functional Sciences (II)

Paraschiva POSTOLACHE, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Faculty of Medicine
Department of Medical Specialties (I)

F. D. PETRARIU, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Faculty of Medicine
Department of Preventive Medicine and Interdisciplinarity

Veronica OPREA, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Faculty of Medicine
Department of Preventive Medicine and Interdisciplinarity
Rehabilitation Clinical Hospital, Iasi
Clinic of Occupational Medicine 

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Published
2018-10-04
Section
PREVENTIVE MEDICINE - LABORATORY