HEPATOTOXICITY – CURRENT CONCEPTS AND MECHANISMS
HEPATOTOXICITY-CURRENT CONCEPTS AND MECHANISMS (Abstract): Liver is the main organ with critical metabolic functions, contributing to the biotransformation of numerous molecules. It has an essential role in converting and clearing of active agents and it is extremely vulnerable to the toxins. The use of chemicals (drugs, abuse substances, poisons, industrial and occupational agents, herbal remedies and dietary supplements) is an important cause of hepatic cells damages, most of them being involved in the development of liver injury. Three types of mechanisms may be responsible for the occurrence of liver toxicity: overdose, drug allergy and idiosyncratic reaction. This review aims to highlight the category of chemicals responsible for the architecture damage and liver function disturbances. The influence of various agents on the liver function may be accompanied by a multitude of manifestations, represented by the increase in liver enzymes activity, hepatocytolysis or liver failure. It is very important to recognize the commonly involved compounds, identify their adverse effects, especially during the drug associations, identify their mechanisms of action, predict and limit their harmful effects in contact with the body. Considering the clinical repercussions of chemical-mediated liver injuries, this review brings into attention several potential hepatotoxic compounds and their pathophysiological mechanisms.
2. Ahmad J, Odin JA. Epidemiology and genetic risk factors of drug hepatotoxicity. Clin Liver Dis. 2017; 21(1): 55-72.
3. Yoon E, Babar A, Choudhary M, et al. Induced Hepatotoxicity a Comprehensive Update. J Clin Translat Hepatol 2016; 4(2): 131-142.
4. Saha A, Shanthi FXM, Winston AB, et al. Prevalence of Hepatotoxicity from Antituberculosis Ther-apy. A Five- Year Experience from South India. J Prim Care Community Health 2016; 7(3): 171-174.
5. Zhang DG, Zhang C, Wang JX, et al. Obethicolic acid protects against carbon tetrachloride induced acute liver injury and inflammation. Toxicol Appl Pharmacol 2017; 314: 39-47.
6. Fukaya S, Yoshioka H, Okano T, et al. Non-toxic Level of Acetaminophen Potentiates Carbon Tetra-chloride-Induced Hepatotoxicity in Mice. Biol Pharm Bull 2017; 40(9): 1590-1594.
7. Atkinson L, Ince P, Smith NM, et al. Toxic reaction to inhaled paint fumes. Postgrad Med J 1989; 65(766): 559-562.
8. Niaz K, Mabqool F, Khan F, et al. Molecular mechanisms of action of styrene toxicity in blood plasma and liver. Environ Toxicol 2017; 32(10): 2256-2266.
9. Soica C, Simu GM, Coricovac D, et al. The toxicity of organic solvents mixtures, containing toluene and its oxidation products. Macedonian Pharmaceutical Bull 2016; 62(suppl 1): 279-280.
10. Wang S, Pacher P, De Lisle RC, Huang H, Ding WX. A Mechanistic Review of Cell Death in Alcohol-Induced Liver Injury. Alcohol Clin Exp Res 2016; 40(6): 1215-1223.
11. McCullought RL, McMullen MR, Sheehan MM et al. Complement Factor D protects mice from ethanol-induced inflammation injury. Am J Gastrointenst Liver Physiol 2018; 315(1): G66-G79.
12. Teplova VV, Kruglov AG, Kovalyov LI, et al. Glutamate contributes to alcohol hepatotoxicity by enhancing oxidative stress in mitochondria. J Bioenerg Biomembr 2017; 49(3): 253-264.
13. Philips CA, Chooracken MJ, Mahadevan P, et al. S(n)orting Out the Problem: Fever of Unknown Origin and Unexplained Abnormal Transaminases in a Young Man. Cureus 2017; 9(8): 1543-1548.
14. Guollo F, Narciso-Schiavon JL, Barotto AM, et al. Significance of alanine aminotransferase levels in patients admitted for cocaine intoxication. J Clin Gastroenterol 2015; 49(3): 250-255.
15. States JC. Arsenic: Exposure Sources, Health Risks, and Mechanisms of Toxicity. In: Hughes MF (editor). Fundamentals of Arsenic Exposure and Metabolism, John Wiley & Sons, 2015, 1-22.
16. Russo MW, Hoofnagle JH, Gu J, et al. Spectrum of Statin Hepatotoxicity. Experience of the Drug Induced Liver Injury Network. Hepatology 2014; 60(2): 679-686.
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