GREEN SYNTHESIZED SILVER NANOPARTICLES VIA PLANT  EXTRACTS AS ANTI-MELANOMA AGENTS

Irina MACOVEI; Anca MIRON; Adina Catinca GRADINARU; Ana Clara APROTOSOAIE

Irina MACOVEI “Grigore T. Popa” University of Medicine and Pharmacy Iasi
Anca MIRON “Grigore T. Popa” University of Medicine and Pharmacy Iasi
Adina Catinca GRADINARU “Grigore T. Popa” University of Medicine and Pharmacy Iasi
Ana Clara APROTOSOAIE “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Abstract

GREEN SYNTHESIZED SILVER NANOPARTICLES VIA PLANT EXTRACTS AS ANTI-MELANOMA AGENTS (Abstract): Melanoma is one of the most common and aggressive type of cancer. The actual treatment includes excisional surgery, electrochemotherapy and pharmacotherapy. The pharmaceutical treatment has major drawbacks such as severe side effects and development of drug resistance, fact that orientated the research towards the formulation of new drug delivery systems. Nanocarriers represent an innovative and alternative tool which significantly improves the bioavailability and site-specific targeting of pharmaceutical agents. Due to their biological activities, flexibility and reliability, silver nanoparticles (AgNPs) have gained high attention. The green synthesis of AgNPs, mediated by a plant extract, is an eco-friendly, cheap and effective method. Green synthesized AgNPs have been reported to develop cytotoxic effects against different tumor cell lines. With respect to melanoma, few studies have been conducted until now, but with promising results. The antitumor activity depends on the size and shape of AgNPs and relies on the synergistic effect between phytochemicals and nanocarriers. Overall, green synthesized AgNPs represent a promising strategy for melanoma treatment.

Author Biographies

Irina MACOVEI, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Faculty of Pharmacy
Department of Pharmacognosy
Department of Drug Analysis

Anca MIRON, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Faculty of Pharmacy
Department of Pharmacognosy

Adina Catinca GRADINARU, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Faculty of Pharmacy
Department of Pharmaceutical Botany

Ana Clara APROTOSOAIE, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Faculty of Pharmacy
Department of Pharmacognosy

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