PYRIDINE-DERIVED SCHIFF BASE-ANALYTICAL REAGENT FOR IRON (II) IONS

  • Gladiola TANTARU “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • M. APOSTU “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Nela BIBIRE “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Madalia VIERIU “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Alina Diana PANAINTE “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Abstract

PYRIDINE-DERIVED SCHIFF BASE-ANALYTICAL REAGENT FOR IRON (II) IONS (Abstract): Aim: Development of a new spectrophotometric method for quantitative determination of Fe (II) ions in pharmaceutical products based on the complexation reaction of the cations with an original Schiff base-2-salicylidene-aminopyridine, when a red complex, extractable in chloroform, with a maximum absorption at 525 nm has formed. Material and methods: A UV-VIS Hewlett-Packard 8453 Spectrophotometer has been used for all determinations. The optimum working conditions of the complexation reaction have been established by studying the influence of pH, ionic strength, and combining ratio on the complexation reaction. Results: The calibration curve had been plotted, and the detection limit was determined (LD=1 mg). The proposed method has a good linearity in the 5-50 μg/mL range with a correlation coefficient r = 0.9946. The stability constant and the molar extinction coefficient were calculated (e = 4.16·104 mol-1·L·cm-1). The cation-ligand ratio was 1:2. The complexation reaction of Fe (II) ions with the Schiff base had no cation interferers, not even Fe (III) ions. Conclusions: The proposed method has been applied for the determination of Fe (II) in pharmaceutical products with very good results.

Author Biographies

Gladiola TANTARU, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Faculty of Pharmacy
Department of Analytical Chemistry

M. APOSTU, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Faculty of Pharmacy
Department of Analytical Chemistry

Nela BIBIRE, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Faculty of Pharmacy
Department of Analytical Chemistry

Madalia VIERIU, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Faculty of Pharmacy
Department of Analytical Chemistry

Alina Diana PANAINTE, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Faculty of Pharmacy
Department of Analytical Chemistry

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Published
2018-10-04