RISK FACTORS FOR COLORECTAL POLYPS: FINDINGS FROM A GREEK CASE-CONTROL STUDY

  • Vasiliki KARAGIANNI ”Saint Panteleimon” General Hospital, Nikea, Athens
  • E. MERIKAS ”Saint Panteleimon” General Hospital, Nikea, Athens
  • F. GEORGEOPOULOS ”Saint Panteleimon” General Hospital, Nikea, Athens
  • A. GIKAS Health Centre of Kalivia, Kalivia-Lagonisi, Athens
  • N. ATHANASOPOULOS ”Saint Panteleimon” General Hospital, Nikea, Athens
  • G. MALGARINOS ”Saint Panteleimon” General Hospital, Nikea, Athens
  • G. PEROS University of Athens
  • J. K. TRIANTAFILLIDIS ”Saint Panteleimon” General Hospital, Nikea, Athens
Keywords: CASE-CONTROL STUDY, COLORECTAL POLYPS, DIET

Abstract

There is a body of evidence showing that several lifestyle
and dietary factors are associated with colorectal polyps formation; however, the magnitude of
this association in diverse populations remains unclear. The aim of this study was to investigate
this association in a Greek sample. Material and method: The study comprised of 52
subjects with histologically confirmed advanced colorectal polyps and 52 healthy controls. Data
concerning lifestyle and dietary factors were collected using a validated questionnaire. Logistic
regression analysis was used to estimate odds ratios and 95% confidence intervals after
adjustment for potential confounders. Results: Physical activity level (95% CI 0.032-0.953,
P=0.044) and consumption of yoghurt (95% CI 0.969-0.996, P=0.024), cheese (95% CI
0.932-0.996, P=0.030), fish (95% CI 0.782-0.964, P=0.008), vegetables (95% CI
0.965-0.998, P=0.029), and garlic (95% CI 0.005-0.671, P=0.022) were inversely associated
with colorectal polyps. Increasing age (95% CI 1.005-1.231, P=0.039) and central
obesity (95% CI 1.001-1.019, P=0.025) were strongly associated with their presence. Conclusion:
Our study indicates that a cluster of modifiable risk factors have significant impact on
colorectal polyps occurrence in Greek population.

Author Biographies

Vasiliki KARAGIANNI, ”Saint Panteleimon” General Hospital, Nikea, Athens

Department of Gastroenterology

E. MERIKAS, ”Saint Panteleimon” General Hospital, Nikea, Athens

Department of Gastroenterology

F. GEORGEOPOULOS, ”Saint Panteleimon” General Hospital, Nikea, Athens

Department of Gastroenterology

N. ATHANASOPOULOS, ”Saint Panteleimon” General Hospital, Nikea, Athens

Department of Gastroenterology

G. MALGARINOS, ”Saint Panteleimon” General Hospital, Nikea, Athens

Department of Gastroenterology

G. PEROS, University of Athens

”Attikon” Hospital
4th Department of Surgery

J. K. TRIANTAFILLIDIS, ”Saint Panteleimon” General Hospital, Nikea, Athens

Department of Gastroenterology

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Published
2019-04-19
Section
INTERNAL MEDICINE - PEDIATRICS