RISK FACTORS FOR COLORECTAL POLYPS: FINDINGS FROM A GREEK CASE-CONTROL STUDY
There is a body of evidence showing that several lifestyle
and dietary factors are associated with colorectal polyps formation; however, the magnitude of
this association in diverse populations remains unclear. The aim of this study was to investigate
this association in a Greek sample. Material and method: The study comprised of 52
subjects with histologically confirmed advanced colorectal polyps and 52 healthy controls. Data
concerning lifestyle and dietary factors were collected using a validated questionnaire. Logistic
regression analysis was used to estimate odds ratios and 95% confidence intervals after
adjustment for potential confounders. Results: Physical activity level (95% CI 0.032-0.953,
P=0.044) and consumption of yoghurt (95% CI 0.969-0.996, P=0.024), cheese (95% CI
0.932-0.996, P=0.030), fish (95% CI 0.782-0.964, P=0.008), vegetables (95% CI
0.965-0.998, P=0.029), and garlic (95% CI 0.005-0.671, P=0.022) were inversely associated
with colorectal polyps. Increasing age (95% CI 1.005-1.231, P=0.039) and central
obesity (95% CI 1.001-1.019, P=0.025) were strongly associated with their presence. Conclusion:
Our study indicates that a cluster of modifiable risk factors have significant impact on
colorectal polyps occurrence in Greek population.
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