CORELAȚII CLINICE ȘI BIOLOGICE PRIVIND VARICELE ESOFAGIENE LA PACIENȚII CU CIROZÃ HEPATICÃ COMPENSATÃ

  • Oana ARHIP Universitatea de Medicină și Farmacie ”Gr. T. Popa” Iași
  • Cristina Cijevschi- PRELIPCEAN Universitatea de Medicină și Farmacie ”Gr. T. Popa” Iași
  • Alina MANOLE Universitatea de Medicină și Farmacie ”Gr. T. Popa” Iași
  • Mioara MATEI Universitatea de Medicină și Farmacie ”Gr. T. Popa” Iași
Keywords: ESOPHAGEAL VARICES, NON-INVASIVE PREDICTORS, LIVER CIRRHOSIS, ENDOSCOPIC SCREENING

Abstract

Material and
methods: The retrospective study included 126 patients with hepatic cirrhosis (HC) CHILD
A class, assisted in Botoºani Hospital, during 2007 and 2008. Patients were clinic, biochemical,
hematological, etiological, ultrasonographic, endoscopical examined. Statistical analysis
carried out with EXCEL soft and SPSS 16.0 soft, calculating chi2, p, ROC curve, SPRI and
ASPRI values. Results: We assessed the sample characteristics using the univariate analysis:
age, the presence / absence of esophageal varices, SPRI score (limit value ³ 15.5), ASPRI
score (limit value ³ 19.3). Conclusions: Non-invasive prediction cannot exclude the endoscopic
exam in patients with compensated HC, caused especially by the virus C and alcohol
consumption. Thrombocytopenia and splenomegaly and Fibroscan exam were the best noninvasive
indicators to predict the esophageal varices.

Author Biographies

Oana ARHIP, Universitatea de Medicină și Farmacie ”Gr. T. Popa” Iași

Doctorand

Cristina Cijevschi- PRELIPCEAN, Universitatea de Medicină și Farmacie ”Gr. T. Popa” Iași

Facultatea de Medicinã
Institutul de Gastroenterologie și Hepatologie

Alina MANOLE, Universitatea de Medicină și Farmacie ”Gr. T. Popa” Iași

Disciplina de Asistențã Primarã a Stãrii de Sãnãtate și Epidemiologie

Mioara MATEI, Universitatea de Medicină și Farmacie ”Gr. T. Popa” Iași

Disciplina de Asistențã Primarã a Stãrii de Sãnãtate și Epidemiologie

References

1. Schepis F, Camma C, Niceforo D et al. Which patients with cirrhosis should undergo endoscopic
screening for esophageal varices detection? Hepatol 2001; 33: 333-338.
2. Merkel C, Zoli M, Siringo S et al. Prognostic indicators of risk for first variceal bleeding in
cirrhosis: a multicenter study in 711 patients to validate and improve the North Italian Endoscopic
Club (NIEC) index. Am J Gastroenterol 2000; 95: 2915-2920.
3. D’Amico G, Pagliaro L. The clinical course of portal hypertension in liver. In: Rossi P ed.
Diagnostic Imaging and Imaging Guided Therapy. Berlin: Springer-Verlag, 2000, 15-24.
4. Vizzutti F, Arena U, Romanelli RG et al. Liver stiffness measurement predicts severe portal
hypertension in patients with HCV-related cirrhosis. Hepatol 2007; 45: 1290–1297.
5. Thomopoulos KC, Labropoulou-Karatza C, Mimidis KP et al. Non-invasive predictors of the
presence of large oesophageal varices in patients with cirrhosis. Dig Liver Dis 2003; 35: 473–478.
6. Madhotra R, Mulcahy HE, Willner I et al. Prediction of esophageal varices in patients with
cirrhosis. J Clin Gastroenterol 2002; 34: 81–85.
7. Ng FH, Wong SY, Loo CK et al. Prediction of oesophagogastric varices in patients with liver
cirrhosis. J Gastroenterol Hepatol 1999; 14: 785–790.
8. Pilette C, Oberti F, Aube C et al. Non-invasive diagnosis of esophageal varices in chronic liver
diseases. J Hepatol 1999; 31: 867–873.
9. Giannini EG, Zaman A, Kreil A et al. Platelet count/spleen diameter ratio for the noninvasive
diagnosis of esophageal varices: Results of a multicenter, prospective, validation study. Am J
Gastroenterol 2006; 101: 2511–2519.
Published
2019-04-19
Section
INTERNAL MEDICINE - PEDIATRICS