COLONOSCOPIC SCREENING OF ASYMPTOMATIC FIRST-DEGREE RELATIVES OF COLORECTAL CANCER PATIENTS
Aim: First-degree relatives of colorectal
cancer (CRC) patients are at increased risk for developing colorectal neoplasm, and
current guidelines recommend screening colonoscopy in such individuals. The aim of this
study was to evaluate the use of colonoscopy as the screening test in asymptomatic first-degree
relatives of CRC patients. Material and method: Colonoscopy was performed in 102 asymptomatic
individuals who had at least one first-degree relatives with CRC. Subjects included in
the screening program were aged between 36 and 72 years, and majority came from two
counties ( Suceava, Iaºi) located in north-eastern Romania. Results: Thirty colorectal lesions
were found in 17 individuals: two (6.6%) had adenocarcinomas, and remaining 15 patients
had 28 polypoid lesions: 14 (46.6%) adenomas, 5 (16.6%) tubulovillous adenomas, 3 (10%)
adenomas with high grade dysplasia and 6 (20%) had hyperplasic polyps. Conclusion:
Colonoscopy is a useful, feasible and safety initial screening tool for first-degree relatives of
patients with CRC.
2007; 1: 39-43.
2. Stanciu C. Cancerul colorectal: epidemiologie, clinica, preventive. Iaºi: Ed. Gr.T. Popa,
3. Levin B, Lieberman DA, McFarland B et al. Screening and surveillance for the early detection of
colorectal cancer and adenomatous polyps. 2008: A Joint Guideline from the American Cancer
Society, The US Multi-Society Task Force on Colorectal Cancer, and the American College of
Radiology. Gastroenterol 2008; 134: 1570-1595.
4. *** National Cancer Institute. SEER cancer statistics review, 1975-2006. 2009. Available at:
http://seer.cancer.gov/csr/1975_2006/. Accessed September 25, 2009.
5. Espey DK, Wu XC, Swan J et al. Annual report to the nation on the status of cancer, 1975-2004,
featuring cancer in American Indians and Alaska Natives. Cancer 2007; 110: 2119-2152.
6. Panteris V. Suggested methods of screening for colorectal cancer. Dig Oncol 2009; 9: 9-14.
7. Rex DK, Johnson D et al. Colorectal cancer prevention 2000: screening recommendations of the
American College of Gastroenterology. Am J Gastroenterol 2000; 95: 868-877.
8. Winawer S, Fletcher R, Rex D et al. Colorectal cancer screening and surveillance: clinical
guidelines and rationale-Update based on new evidence. Gastroenterol 2003; 124: 544-560.
9. Ruthoto F, Papendorf F, Wegener G et al. Participation in screening colonoscopy in first-degree
relatives from patients with colorectal cancer. Ann Oncol 2007; 18: 1518-1522.
10. Pezzoli A, Matarese V, Rubuni M et al. Colorectal cancer screening: Results of a 5-year program
in asymptomatic subjects at increased risk. Dig Liver Dis 2007; 39: 33-39.
11. James D, John B, Francis T et al. Cancer risk in relatives of patients with common colorectal
cancer. Ann Int Med 1993; 118: 785-790.
12. Guillem J, Forde K, Treat M et al. Colonoscopic screening for neoplasms in asymptomatic
first-degree relatives of colon cancer patients. Dis Colon Rectum 1992; 35: 523-529.
13. Pariente A, Milan C, Lafon J et al. Colonoscopic screening in first-degree relatives of patients with
sporadic colorectal cancer: A case-control study. Gastroenterol 1998; 115: 7-12.
14. Colombo L, Corti G, Magri F et al. Results of a pilot study of endoscopic screening of first-degree
relatives of colorectal cancer patients in Italy. J Epidemiol Community Health 1997; 51: 453-458.
15. Baker J, Gathright B, Timmcke A et al. Colonoscopic screening of asymptomatic patients with
family history of colon cancer. Dis Colon Rectum 1990; 33: 926-930.
16. Syrigos KN, Charalampopoulos A, Ho JL et al. Colonoscopy in asymptomatic individuals with a
family history of colorectal cancer. Ann Surg Oncol 2002; 9: 439-443.
17. Wu CH, Tung SY, Chen PC, Kuo YC. The role of colonoscopy in screening persons with family
history of colorectal cancer. J Gastroenterol Hepatol 2008; 10: 319-323.
18. Bazzoli F, Fossi S, Sottoli S et al. The risk of adenomatous polyps in asymptomatic first-degree
relatives of persons with colon cancer. Gastroenterol 1995; 109: 783-788.
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