• Elena TOADER Universitatea de Medicină și Farmacie ”Gr. T. Popa” Iași
  • Cecilia DURNEA Institutul de Sãnãtate Publicã Iași


Perinuclear anti-neutrophil cytoplasmic antibodies (p-ANCA) are
more common in patients with ulcerative colitis (UC) than in patients with Crohns disease
(CD), but its prevalence depends on the population being studied and the method employed for
its detection. Aim: To determinate the prevalence of p-ANCA in ulcerative colitis (UC) patients
and their first degree in NE Romania area. Material and method: In this study, we investigated
the prevalence of p-ANCA as detected by ELISA, in the serum of 44 patients with UC
and 22 first degree relatives. We also correlated the presence of this antibody with disease
activity and extent, extraintestinal complications and therapy. 26 healthy individuals comprised
the control group. Results: p-ANCA was detected in 11% of the patients with UC. Of the 5
p-ANCA positive UC patients, 1 case were found to have proctosigmoiditis, 1 cases had
left-sided colitis and 3 cases had pancolitis. There was no correlation between the presence of
this antibody and any of the studied clinical variables (extend disease, complication, family
disease, surgery). No person of the first degree and control group presented positive test.
Conclusions: The prevalence of p-ANCA in NE Romania patients with UC (11 %) is lower
than that in the Western population. The negativity of p-ANCA in all first degree relatives of
NE Romania UC patients should be further elucidated.

Author Biography

Elena TOADER, Universitatea de Medicină și Farmacie ”Gr. T. Popa” Iași

Facultatea de Medicinã
Institutul de Gastroenterologie și Hepatologie Iași


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