• Paula POPOVICI Universitatea de Medicină și Farmacie ”Gr. T. Popa” Iași
  • Evelina MORARU Universitatea de Medicină și Farmacie ”Gr. T. Popa” Iași


Aim: Plurietiological hepatic cholestasis involves an increased risk of protein-
-caloric malnutrition and specifical nutritional deficiencies. Biological investigations to determine
deficiencies in fat-soluble vitamins are essential for specific nutritional therapy . Although
malnutrition is not an absolute contraindication for liver transplantation, its gravity has complex
consequences in relation to this intervention. Material and method: The authors present a
study conducted over a period of 5 years following the analysis of 293 children diagnosed with
intra-or extrahepatic abnormalities that caused varying degrees of cholestasis. Results: In the
study group, the percentage of infants with cholestasis was 45.39% (133 cases) and among
them 62.12% had malnutrition (82 children). Clinical evaluation of fat-soluble vitamins deficiency,
in particular, but also of the soluble and minerals was performed in all patients. Liver
transplantation was successfully performed in three cases. Conclusions: Most important
factors affecting growth after transplantation were age at the time of the liver transplant and
primary diagnosis that required transplant. The role of nutritional support prior to liver
transplantation is of great importance. Quality nutritional support change impact that malnutrition
has on survival after liver transplantation.

Author Biographies

Paula POPOVICI, Universitatea de Medicină și Farmacie ”Gr. T. Popa” Iași

Facultatea de Medicinã
Clinica a II-a Pediatrie

Evelina MORARU, Universitatea de Medicină și Farmacie ”Gr. T. Popa” Iași

Facultatea de Medicinã
Clinica a II-a Pediatrie


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