ASPECTE CLINICO-EVOLUTIVE ALE MENINGITEI TUBERCULOASE LA COPIL
The aim of the study was to investigate the particularities of the clinical manifestation
and evolution of tuberculous meningitis at children. Material and method: The study
was made between January 2000 and December 2008 in Clinic of Infectious Diseases Iaºi and
Emergency County Hospital Sf. Ioan cel Nou Suceava on a group of 169 children with
tuberculous meningitis. Results: The majority (78.1%) of patients had poor socio-economic
conditions and 22.4$ had a family TB contact. The onset of the symptoms was atypical in
infants and small children with fever associated with digestive, neurological or pulmonary
manifestations. The admission in hospital was delayed in 56.8% of patients and 39.05% had a
severe general status with coma. The positive diagnosis was based on cytological and biochemical
features of CSF, results of QuantilFERON. TB Gold, pulmonary images, family TB contact
and evolution under anti-tuberculous therapy. We observed a high rate of complications represented
by hydrocephaly (28.9%). 18 patients died (4 infants), the cause of dead being
meningeal coma or complications. Conclusion: The diagnosis of tuberculous meningitis at
children remains a problem because of the atypical clinical manifestation, the delay of initiating
the therapy causing high mortality and frequent complications.
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