EARLY RECURRENCE IN FAVORABLE STAGE II BREAST CANCER - WHICH APPROACH IS THE BEST?
Aim: Changing the sequence of therapeutic options in
stage II breast cancer: first, a core biopsy, followed by the evaluation of the tumoral markers,
adaptation of the chemotherapy scheme and finally, surgical approach. Thus would be possible
to improve the hope of life in some stage II breast cancer patients, in whom survival is poorer
than in some stage III patients. Material and method: 144 patients in stage II breast cancer
were included in this study, over a period of 5 years (2000-2004). In all these patients the first
therapeutic option was surgery (radically modified mastectomy type Madden), followed by
systemic chemotherapy-FAC or FEC, 6 cycles, and finally Tamoxifen. Results: 34 out of them
developed metastases in a period between 6 and 72 months, most of them in the first 26
months; 25 out of these 34 didnt have metastases in the axillary lymph nodes, and in 18
patients estrogen - and progesterone - receptors were highly positive. HER 2 neu was negative
or low expressed in patients with metastases. CD 34 wasnt evaluate in the whole group.
Conclusions: Early onset of metastases in the studied patients, in whom tumoral aggressiveness
markers were not obvious, impose the evaluation of the angiogenesis markers and, when
positive, chemotherapy as the first therapeutic option.
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