SERUM LIPOPROTEIN (a) LEVELS IN PATIENTS WITH ARTERIAL HYPERTENSION
Lp(a) is capable of deleteriously altering the balance between the procoagulant
and anticoagulant, proinflammatory and anti-inflammatory, and vasorelaxing and vasoconstricting
properties of the endothelium. Material and method: The purpose of this study was to
investigate the serum concentration of Lp(a) and the main parameters of lipid profile in three
groups of subjects: a control group that included 16 healthy subjects, 20 patients with arterial
hypertension and dyslipidemia and 20 patients with arterial hypertension without dyslipidemia.
Using B-mode ultrasonography, we evaluated carotid intima-media thickness (IMT) and flow
mediated vasodilation (FMD) on brachial artery. Results: We found significant higher Lp(a)
concentrations in hypertensive patients with dislipidemia (70±55.95 mg/dL, p<0.001) and in
hypertensive patients without dislipidemia (69±52.33 mg/dL, p<0.001), comparative with the
control group (19±14.64 mg/dL). In hypertensive patients with dislipidemia we found a
strong negative correlation between Lp(a) and carotid IMT (R2 = -0.75, p<0.001) and a
moderate negative correlation between Lp(a) and FMD (R2 = - 0.38, p<0.001). Lp(a) level
wasnt correlated with the main parameters of lipid profile. Conclusions: These results
indicated that serum Lp(a) values could play an important role in essential hypertension
pathogenesis and could be considered as an individual risk factor in hypertensive patients.
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