GHRELIN AND ANG 1-7 HAVE VASODILATATORY CUMULATIVE EFFECTS ON PULMONARY VESSELS

  • Maria DINCA ”Gr.T. Popa” University of Medicine and Pharmacy Iași
  • Irina Luciana DUMITRIU ”Gr.T. Popa” University of Medicine and Pharmacy Iași
  • Mihaela Beatrice GURZU ”Gr.T. Popa” University of Medicine and Pharmacy Iași
  • Simona Mihaela SLATINEANU ”Gr.T. Popa” University of Medicine and Pharmacy Iași
  • Liliana FOIA ”Gr.T. Popa” University of Medicine and Pharmacy Iași
  • Luminita VATA ”Gr.T. Popa” University of Medicine and Pharmacy Iași
  • Elena COJOCARU ”Gr.T. Popa” University of Medicine and Pharmacy Iași
  • Gh. PETRESCU ”Gr.T. Popa” University of Medicine and Pharmacy Iași
Keywords: GHRELIN, ANGIOTENSIN 1-7, PULMONARY RAT ARTERY, NITRIC OXIDE

Abstract

Ghrelin is an orexigenic hormone that has been shown
to have vasodilator effects. Angiotensin 1-7 (Ang 1-7) is a bioactive component of the
renin-angiotensin system and may play an important role in the regulation of cardiovascular
homeostasis. Aim: The aim of this study was to investigate the interaction between ghrelin
and a better known vasodilatator, Ang 1-7. Material and method: The dose dependent
relaxing effects of ghrelin were assesed on pulmonary artery rings of male Wistar rats with
intact endothelium in the absence or the presence of Ang 1-7. Ang 1-7 was added in the organ
bath with 5 minutes before NG-nitro L-arginine methyl ester (L-NAME, 1 µM) and indomethacin
administration in the presence of cumulative doses of ghrelin. Results: Our results
showed that Ang 1-7 could improve and restore vasorelaxant effects of ghrelin on rat pulmonary
rings with intact endothelium. Conclusion: Vasodilatatory actions of ghrelin are potentiated by
Ang 1-7 and mediated by local synthesis of prostaglandins and nitric oxide.

Author Biographies

Maria DINCA, ”Gr.T. Popa” University of Medicine and Pharmacy Iași

School of Medicine
Functional Sciences Department

Irina Luciana DUMITRIU, ”Gr.T. Popa” University of Medicine and Pharmacy Iași

School of Medicine
Functional Sciences Department

Mihaela Beatrice GURZU, ”Gr.T. Popa” University of Medicine and Pharmacy Iași

School of Dentistry
Department of Semiology and Prevention

Simona Mihaela SLATINEANU, ”Gr.T. Popa” University of Medicine and Pharmacy Iași

School of Medicine
Functional Sciences Department

Liliana FOIA, ”Gr.T. Popa” University of Medicine and Pharmacy Iași

School of Dentistry
Department of Semiology and Prevention

Luminita VATA, ”Gr.T. Popa” University of Medicine and Pharmacy Iași

School of Medicine
Functional Sciences Department

Elena COJOCARU, ”Gr.T. Popa” University of Medicine and Pharmacy Iași

School of Medicine
Functional Sciences Department

Gh. PETRESCU, ”Gr.T. Popa” University of Medicine and Pharmacy Iași

School of Medicine
Functional Sciences Department

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Published
2019-11-12