EFECTELE SUPLIMENTÃRII DIETEI CU ACIZI GRAȘI POLINESATURAȚI OMEGA 3 ȘI ACETILCISTEINÃ ASUPRA PERFORMANȚEI ÎN ÎNVÃȚARE
Omega-3 fatty acids are essential for
human health, are crucial for the brain, body development and also in prevention of cardiovascular
diseases. Material and method: We used 60 male Wistar rats, weight 180 ± 20 grams,
divided into two study groups: normal control animals (M) and test animals (T) divided in
groups I (N3-PUFA), II (ACC) and III (N3-PUFA and ACC). Administration of the substances
was made for 36 weeks (nine months), after which the animals were evaluated and subsequently
sacrificied for further biochemical analysis. As an evaluation method has been used multiple T
maze labyrinth. Results: Group I recorded a time maze percentage decrease from -4.26% to
-33.88%. In group II we recorded a decrease time maze percentage from -5.37% to -34.28%.
During the experiment, group III recorded a decrease time maze percentage from -5.1% to
-32.33% at the end of the experiment. The control group evolution for the maze recorded a
decrease in time maze percentage, reaching 17-18% at the end of the experiment. Conclusion:
By improving the diet with polyunsaturated fatty acids increased exponentially cognitive
performance compared with normal diet, low in these acids.
composition of nerve membranes, enzymatic activity, amplitude of electrophysiological parameters,
resistance to poisons and performance of learning tasks in rats. J Nutr 1989; 119: 18801892.
2. Lamptey MS, Walker BL. A possible essential role for dietary linolenic acid in the development of
the young rat. J Nutr 1976; 106: 8693.
3. Wainwright PE, Huang YS, Bulman-Fleming B, Lévesque S, McCutcheon D. The effects of
dietary fatty acid composition combined with environmental enrichment on brain and behavior in
mice. Behav Brain Res 1994; 60: 125136.
4. Francès H, Monier C, Bourre JM. Effects of dietary alpha-linolenic acid deficiency on neuromuscular
and cognitive functions in mice. Life Sci 1995; 57: 19351947.
5. Francès H, Monier C, Clément M et al. Effect of dietary alpha-linolenic acid deficiency on
habituation. Life Sci 1996; 58: 18051816.
6. Francès H, Coudereau JP, Sandouk P et al. Influence of a dietary alpha-linolenic acid deficiency on
learning in the Morris water maze and on the effects of morphine. Eur J Pharmacol 1996; 298: 217225.
7. Carrié I, Clément M, de Javel D, Francès H, Bourre JM. Learning deficits in first generation OF1
mice deficient in (n-3) polyunsaturated fatty acids do not result from visual alteration. Neurosci Lett
1999; 266: 6972.
8. Nakashima Y, Yuasa S, Hukamisu Y et al. Effect of a high linoleate and a high alpha-linolenate diet
on general behavior and drug sensivity in mice. J Lipid Res 1993; 34: 239247.
9. Yamamoto N, Hashimoto A, Takemoto Y et al. Effect of the dietary alpha-linolenate/linoleate
balance on lipid compositions and learning ability of rats. Discrimination process, extinction
process, and glycolipid compositions. J Lipid Res 1988; 29: 10131021.
10. Coscina DV, Yehuda S, Dixon LM, Kish LM, Leprohon CE. Learning is improved by a soybean
oil diet in rats. Life Sci 1986; 38: 17891794.
11. Jensen MM, Skarsfeeldt T, Hoy CE. Correlation between level of (n-3) polyunsaturated fatty acids
in brain phospholipids and learning ability in rats. A multiple generation study. Biochim Biophys
Acta 1996; 1300: 203209.
Once an article is accepted for publication, MSJ requests a transfer of copyrights for published articles.
COPYRIGHT TRANSFER FORM FOR
REVISTA MEDICO-CHIRURGICALĂ A SOCIETĂȚII DE MEDICI ȘI NATURALIȘTI DIN IAȘI /
THE MEDICAL-SURGICAL JOURNAL OF THE SOCIETY OF PHYSICIANS AND NATURALISTS FROM IASI
We, the undersigned authors of the manuscript entitled
warrant that this manuscript, which is submitted for publication in the REVISTA MEDICO-CHIRURGICALĂ, has not been published and it is not under consideration for publication in another journal.
- we give the consent for publication in the REVISTA MEDICO-CHIRURGICALĂ, in printed and electronic format and we transfer unconditioned and complete the copyright of this manuscript to the REVISTA MEDICO-CHIRURGICALĂ, in the event of its acceptance.
- the manuscript does not break the intellectual property rights of any other person.
- we have read the submitted version of the manuscript and we are fully responsible for the content.
Names and signatures of authors / copyright owners (the following sequence is the authorship of the article):
N.B. All the authors must sign this form