IN VITRO EVALUATION OF KETOPROFEN CONTROLLED RELEASE FROM VARIOUS FORMULATIONS
The aim of this study is to investigate the potential utility
of some hydrogels, based on chitosan, chitosan modified with phthalic anhydride and 75/25
poly(N-isopropyl acrylamide)/alginate, for preparing drug release systems containing ketoprofen,
as model drug. Material and method: The in vitro release profiles and swelling
studies were done in ethanol medium, where the studied drug presents high solubility, at 250C
(room temperature). The ketoprofen release was observed by monitoring the absorbance at lmax
= 254 nm as a function of time. Results: The experimental results indicated that the smallest
amount of drug was released from chitosan matrices, appreciatively 31%. Conclusions: The
composition of hydrogels had an important effect on ketoprofen release.
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