IN VITRO EVALUATION OF KETOPROFEN CONTROLLED RELEASE FROM VARIOUS FORMULATIONS

  • Ana - Maria OPREA ”P. Poni” Institute of Macromolecular Chemistry Iași
  • Raluca Petronela DUMITRIU ”P. Poni” Institute of Macromolecular Chemistry Iași
  • Catalina CHEABURU ”P. Poni” Institute of Macromolecular Chemistry Iași
  • Cornelia VASILE ”P. Poni” Institute of Macromolecular Chemistry Iași
Keywords: ALGINATE, CHITOSAN, SWELLING, CONTROLLED RELEASE, KETOPROFEN

Abstract

The aim of this study is to investigate the potential utility
of some hydrogels, based on chitosan, chitosan modified with phthalic anhydride and 75/25
poly(N-isopropyl acrylamide)/alginate, for preparing drug release systems containing ketoprofen,
as model drug. Material and method: The in vitro release profiles and swelling
studies were done in ethanol medium, where the studied drug presents high solubility, at 250C
(room temperature). The ketoprofen release was observed by monitoring the absorbance at lmax
= 254 nm as a function of time. Results: The experimental results indicated that the smallest
amount of drug was released from chitosan matrices, appreciatively 31%. Conclusions: The
composition of hydrogels had an important effect on ketoprofen release.

Author Biographies

Ana - Maria OPREA, ”P. Poni” Institute of Macromolecular Chemistry Iași

Physical Chemistry of Polymers Department

Raluca Petronela DUMITRIU, ”P. Poni” Institute of Macromolecular Chemistry Iași

Physical Chemistry of Polymers Department

Catalina CHEABURU, ”P. Poni” Institute of Macromolecular Chemistry Iași

Physical Chemistry of Polymers Department

Cornelia VASILE, ”P. Poni” Institute of Macromolecular Chemistry Iași

Physical Chemistry of Polymers Department

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Published
2019-11-12