GRAPEFRUIT JUICE – DRUG INTERACTIONS: IMPORTANCE FOR PHARMACOTHERAPY

  • Magdalena CUCIUREANU ”Gr.T. Popa” University of Medicine and Pharmacy Iași
  • L. VLASE ”I. Hațieganu” University of Medicine and Pharmacy Cluj-Napoca
  • Dana MUNTEAN ”I. Hațieganu” University of Medicine and Pharmacy Cluj-Napoca
  • Irina VARLAN ”Gr.T. Popa” University of Medicine and Pharmacy Iași
  • Rodica CUCIUREANU ”Gr.T. Popa” University of Medicine and Pharmacy Iași
Keywords: GRAPEFRUIT, PHARMACOKINETIC INTERACTION, BIOAVAILABILITY

Abstract

In spite of known health benefits of grapefruit juice, its consumption
in combination with drugs requires caution. The drugs most susceptible to pharmacokinetic
interactions with clinical significance are those with narrow therapeutic index and low bioavailability
due to important first-pass metabolism. Most vulnerable populations are elderly,
cirrhotics, subjects with genetic polymorphisms and individuals taking other CYP3A4 inhibitors.
The major drug classes that have been reported to present interactions with grapefruit juice
are antiallergics, antibiotics, antimalaria drugs, anxiolytics, calcium channel blockers, HIV
protease inhibitors, HMG-CoA reductase inhibitors; the degree of pharmacokinetic interaction
varies among the compounds of the same class.

Author Biographies

Magdalena CUCIUREANU, ”Gr.T. Popa” University of Medicine and Pharmacy Iași

School of Dental Medicine
Department of Pharmacology

L. VLASE, ”I. Hațieganu” University of Medicine and Pharmacy Cluj-Napoca

School of Pharmacy
Department of Pharmaceutical Technology and Biopharmaceutics

Dana MUNTEAN, ”I. Hațieganu” University of Medicine and Pharmacy Cluj-Napoca

School of Pharmacy
Department of Pharmaceutical Technology and Biopharmaceutics

Irina VARLAN, ”Gr.T. Popa” University of Medicine and Pharmacy Iași

School of Pharmacy
Department of Environmental and Food Chemistry

Rodica CUCIUREANU, ”Gr.T. Popa” University of Medicine and Pharmacy Iași

School of Pharmacy
Department of Environmental and Food Chemistry

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Published
2019-11-14