DRUG RESISTANT EPILEPSY DUE TO BILATERAL PERIVENTRICULAR NODULAR HETEROTOPIA. CASE REPORT

  • R.I. CARCALICI Emergency Academic Hospital Sibiu
  • Corina ROMAN-FILIP Emergency Academic Hospital Sibiu

Abstract

Periventricular nodular heterotopia (PNH) is among the most frequent malformations of cortical development due to disturbance in neuronal migration and is associated with intractable epilepsy. Neuronal migration disorders cause severe syndromes, including refractory epilepsy and major psychomotor development disorders. It has been demonstrating that approximately  80% of familial cases of PNH are related to FLNA mutation, gene located on the long arm of the X-chromosome inherited in a dominant fashion. A constellation of syndromes, including heterotopic nodules with intractable epilepsy, microcephaly, and severe develop-mental delay is seen in ARFGEF2 mutations, a gene located in chromosome 20 with an autosomal recessive inheritance pattern. We present a case of 18-years old patient, right-handed, without   remarkable findings in personal history of childhood, with normal social and psychiatric development. At the age of 15 she was admitted in the department of Psychiatry for depression and behavioral disorder (irritability and aggressive behavior) and she was treated with selective serotonin reuptake inhibitors (this happens frequently showed a small study which revealed that EEG can be abnormal in patients with neurotic disorders.

Author Biographies

R.I. CARCALICI, Emergency Academic Hospital Sibiu

Department of Neurology

Corina ROMAN-FILIP, Emergency Academic Hospital Sibiu

Department of Neurology 
“Lucian Blaga” University of Sibiu

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Published
2019-12-29
Issue
Vol 123 No 4 (2019): The Medical-Surgical Journal
Section
INTERNAL MEDICINE - PEDIATRICS

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