HEMOLYSIS - AT THE BORDER OF THE CONTROVERSY OR MALPRACTICE

Authors

  • Carmen DELIANU Grigore T. Popa University of Medicine and Pharmacy, Iasi, Romania
  • Loredana Liliana HURJUI Grigore T. Popa University of Medicine and Pharmacy, Iasi, Romania
  • Mihaela MOSCALU “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Claudia Cristina TĂRNICERIU “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • I. HURJUI “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Oana-Viola BĂDULESCU “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Liliana FOIA “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Abstract

Clinical laboratory medicine provides nowadays significant level of reliability of adequate measurement and testing, as well as a quality assurance in hemostasis assays through modern analyzers. However, many non-conforming samples are still recorded and reported due to events which are not always under the control of the laboratories. Numerous studies indicate that most sources of error in hemostasis laboratories occur with the blood collection procedure for prothrombin time (PT) and activated partial thromboplastin time (APTT) determination. The purpose of this study is to provide a better understanding upon the potential interference between hemolysis and in vitro coagulation mechanism. Materials: In order to create a comprehensive approach to the effect of hemolysis on hemostasis determinations, we performed a search in the main databases which included original studies reviewed by specialists in this field. Results: For the clinical laboratory, hemolysis is the most frequent error of the samples, accounting for 54-65% of all non-compliant samples. We have referred to studies in which hemolysis was mechanically provoked, studies that were based only on macroscopic identification, and last but not least, on studies in which plasma hemoglobin concentration was determined. Conclusions: This study could represent the premise for revising the policy of refusing the hemolyzed samples as a result of the controversial outcomes that are not considered clinically relevant.

Author Biographies

  • Carmen DELIANU, Grigore T. Popa University of Medicine and Pharmacy, Iasi, Romania

    . “Sf. Spiridonˮ County Clinical Emergency Hospital, Iași, Romania

  • Loredana Liliana HURJUI, Grigore T. Popa University of Medicine and Pharmacy, Iasi, Romania

    “Sf. Spiridonˮ County Clinical Emergency Hospital, Iași, Romania

  • Claudia Cristina TĂRNICERIU, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

    “Sf. Spiridonˮ County Clinical Emergency Hospital, Iași, Romania

  • Oana-Viola BĂDULESCU, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

    “Sf. Spiridonˮ County Clinical Emergency Hospital, Iași, Romania

  • Liliana FOIA, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

    “Sf. Spiridonˮ County Clinical Emergency Hospital, Iași, Romania

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Additional Files

Published

2020-06-30

Issue

Vol. 124 No. 2 (2020): The Medical-Surgical Journal

Section

PREVENTIVE MEDICINE - LABORATORY

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