PRIMARY CUTANEOUS PERIVASCULAR EPITHELIOID CELL TUMOR (PEComa). CASE REPORT AND REVIEW OF THE LITERATURE
PEComas represent a family of uncommon mesenchymal tumors that can develop on the skin and also can affect internal organs with a distinct immunophenotype that typically shows both myogenic and melanocytic differentiation. We present the case of a 49 years old female patient, from urban area, who was hospitalized in Dermatology Clinic Craiova for the presence of a 2 cm diameter tumor, round shaped, reddish-pink, with smooth surface, located on the internal site of the right thigh. The diagnosis of primary cutaneous PEComa was confirmed histopathologicaly and immunohistochemically and from the clinical point of view it represents a challenge for the dermatologist.
2. Nwabudike LC, Elisei AM, Buzia OD, Miulescu M, Tatu, AL. Statins. A Review on Structural Per-spectives, Adverse Reactions and Relations with Non-melanoma Skin Cancer. Rev Chim (Bucharest) 2018; 69(6): 2557-2562.
3. Ciobotaru OR, Voinescu DC, Ciobotaru OC, Voicu D, Arbune M. Expression of p53 and Ki-67 in distal oesophageal and gastric cardia adenocarcinomas. Rom Biotech Lett 2015; 20(5): 10800-10808.
4. Zamboni G, Pea M, Martignoni G, Zancanaro C, Faccioli G, Gilioli E, Pederzoli P, Bonetti F. Clear cell “sugar” tumor of the pancreas. A novel member of the family of lesions characterized by the presence of perivascular epithelioid cells. Am J Surg Pathol 1996; 20: 722.
5. Ieremia E, Robson A. Cutaneous PEComa: a rare entity to consider in an unusual site. Am J Dermat-opathololy 2014; 36: e198-e201.
6. Mar Llamas-Velasco, Luis Requena, and Thomas Mentzel, Cutaneous perivascular epithelioid cell tumors: A review on an infrequent neoplasm, World J Methodology 2016; 6(1): 87-92.
7. Brănișteanu DE, Brănișteanu DC, Stoleriu G, Ferariu D, Voicu CM, Stoica LE, Căruntu C, Boda D, Filip-Ciubotaru FM, Dimitriu A, Radu CD. Histopathological and clinical traps in lichen sclerosus: a case report. Rom J Morphol Embryol 2016; 57(Suppl 2): 817-823.
8. Vasincu D, Iancu RI, Chelaru L, Stoleriu G, Costuleanu M. Biochemical Effects of Some Endoplasmic Reticulum Stress Inducers on Mesenchymal Stem Cells in vitro. REV.CHIM.(Bucharest) 2018; 69(6): 1570-1573.
9. Liegl B, Hornick JL, Fletcher CD. Primary cutaneous PEComa: distinctive clear cell lesions of skin. Am J Surgical Pathology 2008; 32: 608-614.
10. Tan J, Peach AH, Merchant W. PEComas of the skin: more common in the lower limb? Two case reports. Histopathology 2007; 51: 135-136.
11. Filip-Ciubotaru F, Manciuc C, Stoleriu G, Foia L. NADPH Oxidase: structure and activation mecha-nisms (review). Note I. Rev Med Chir Soc Med Nat Iasi 2016; 120(1): 29-33.
12. Charli-Joseph Y, Saggini A, Vemula S, Weier J, Mirza S, LeBoit PE. Primary cutaneous perivascular epithelioid cell tumor: a clinicopathological and molecular reappraisal. JADD 2014; 71(6): 1127-1136.
13. Stuart LN, Tipton RG, DeWall MR, Parker DC. Primary cutaneous perivascular epithelioid cell tumor (PEComa): Five new cases and review of the literature. J Cutan Pathol 2017; 44(8): 713-721.
14. Brănișteanu DE, Pintilie A, Andreș LE, Dimitriu A, Oanță A, Stoleriu G, Brănișteanu DC. Ethiopato-genic hypotheses in lichen planus. Rev Med Chir Soc Med Nat Iasi 2016; 120(4): 760-767.
15. Calder KB, Schlauder S, Morgan MB. Malignant perivascular epithelioid cell tumor (‘PEComa’): a case report and literature review of cutaneous/ subcutaneous presentations. J Cutan Pathology 2008; 35: 499-503.
16. Chaplin A, Conrad DM, Tatlidil C, Jollimore J, Walsh N, Covert A, Pasternak S. Primary cutaneous PEComa. Am J Dermatopathology 2010; 32: 310-312.
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