CHEMICAL PERSPECTIVE ON ANTI-AGING PROPERTIES OF SOME PHENOLICS FROM PLANTS

  • Gabriela TATARINGA “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Ana-Maria ZBANCIOC “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Abstract

Nowadays it is well-accepted that topical polyphenol-rich products can reverse partially the clinical and histological changes in the epidermis and dermis induced by the combination of sunlight exposure and chronologic aging. Natural compounds used against photoaging comprise phenolic compounds, including flavonoids, phenolic acids (benzoic, gallic, cinnamic acids) and stilbenes derived from plants such as tea, grape, bergamot, rooibos, grapefruit, red orange. It was reported that many polyphenols from plants exhibit inhibitory activity against collagenases and elastases. Phenolic derivatives are efficient protectors through reduction of oxidative stress, inflammation and immunosuppression and may be important components in cosmetic formulations.

Author Biographies

Gabriela TATARINGA, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Faculty of Pharmacy
Departament of Pharmaceutical Sciences (I)

Ana-Maria ZBANCIOC, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Faculty of Pharmacy
Departament of Pharmaceutical Sciences (I)

References

1. Sjerobabski-Masnec I, Situm M. Skin aging. Acta Clin Croat 2010; 49(4): 515-518.
2. Jimenez F, Mitts TF, Liu K, Wang Y, Hinek A. Ellagic and tannic acids protect newly synthesized elastic fibers from premature enzymatic degradation in dermal fibroblast cultures. J Invest Dermatol 2006; 126(6): 1272-1280.
3. Gilchrest BA. A review of skin aging and its medical therapy. Br J Dermatol 1996; 135(6): 867-75.
4. Saraf S, Kaur CD. Phytoconstituents as photoprotective novel cosmetic formulations. Pharmacogn Rev 2010; 4(7): 1-11.
5. Kohl E, Steinbauer J, Landthaler M, Szeimies RM. Skin aging. J Eur Acad Dermatol Venereol 2011; 25(8): 873-884.
6. Chiang HM, Lin TJ, Chiu CY, et al. Coffea arabica extract and its constituents prevent photoaging by suppressing MMPs expression and MAP kinase pathway. Food Chem Toxicol 2011; 49(1): 309-318.
7. Petruk G, Giudice R, Rigano MM, Monti DM. Antioxidants from Plants Protect against Skin Pho-toaging. Oxidative Medicine and Cellular Longevity 2018; Volume 2018, Article ID 1454936.
8. Ullrich A, Schlessinger J. Signal transduction by receptors with tyrosine kinase activity. Cell 1990; 61(2): 203-212.
9. Gross S, Knebel A, Tenev T, et al. Inactivation of protein tyrosine phosphatases as mechanism of UV-induced signal transduction, Journal of Biological Chemistry 1999; 274(37): 26378-26386.
10. Fisher GJ, Kang S, Varani J, et al. Mechanisms of photoaging and chronological skin aging. Archives of Dermatology 2002; 138(11): 1462-1470.
11. Matsumura Y, Ananthaswamy H.N. Toxic effects of ultraviolet radiation on the skin. Toxicology and Applied Pharmacology 2004; 195(3): 298-308.
12. Pulok K Mukherjeea, Niladri Maitya, Neelesh K. Nemaa, Birendra K. Sarkar. Bioactive compounds from natural resources against skin aging. Phytomedicine 2011; 19: 64- 73.
13. Soto ML, Falqué E, Domínguez H. Relevance of Natural Phenolics from Grape and Derivative. Prod-ucts in the Formulation of Cosmetics. Cosmetics 2015; 2: 259-276.
14. Działo M, Mierziak J, Korzun U, Preisner M, Szopa J, Kulma A. The Potential of Plant Phenolics in Prevention and Therapy of Skin Disorders. Int J Mol Sci 2016; 17: 160-166.
15. Saxena M. Saxena J, Pradhan A. Flavonoids and phenolic acids as antioxidants in plants and human health. Int J Pharm Sci Rev Res 2012; 16: 130-134.
16. Arct J, Oborska A, Mojski M, Binkowska A, Awidzikowska B. Common cosmetic hydrophilic ingre-dients as penetration modifiers of flavonoids. Int J Cosmet Sci 2002; 24(6): 357-366.
17. Valcic S, Burr JA, Timmermann BN, Liebler DC. Antioxidant chemistry of green tea catechins. New oxidation products of (¡)-epigallocatechin gallate and (¡)-epigallocatechin from their reactions with peroxyl radicals. Chem. Res Toxicol 2000; 13: 801-810.
18. Dudonne S, Vitrac X, Coutiere P, Woillez M, Merillon JM. Comparative Study of Antioxidant Prop-erties and Total Phenolic Content of 30 Plant Extracts of Industrial Interest Using DPPH, ABTS, FRAP, SOD, and ORAC Assays. J Agric Food Chem 2009; 57(5): 1768-1774.
19. Makimura M, Hirasawa M, Kobayashi K, et al. Inhibitory effect of tea catechins on collagenase activity. J. Periodontol 1993: 4: 630-636.
20. Madhan B, Krishnamoorthy G, Rao JR, Nair B U. Role of green tea polyphenols in the inhibition of collagenolytic activity by collagenase. Int J Biol Macromol 2007; 41: 16-22.
21. Jackson JK, Zhao J, Wong W, Burt HM. The inhibition of collagenase induced degradation of collagen by the galloyl-containing polyphenols tannic acid, epigallocatechin gallate and epicatechin gallate. J Mater Sci Mater Med 2010; 21: 1435-1443.
22. Roh E, Kim JE, Kwon JY, et al. Molecular mechanisms of green tea polyphenols with protective effects against skin photoaging. Critical Reviews in Food Science and Nutrition 2017; 57 (8): 1631-1637.
23. Katiyar SK, Matsui MS, Elmets CA, Mukhtar H. Polyphenolic antioxidant (-)-epigallocatechin-3-gallate from green tea reduces UVB-induced inflammatory responses and infiltration of leukocytes in human skin. PhotochemPhotobiol 1999; 69(2): 148-153.
24. Wei H, Zhang X, Zhao JF, et al.Scavenging of hydrogen peroxide and inhibition of ultraviolet light induced oxidative DNA damage by aqueous extracts from green and black teas. Free Radic Biol Med 1999; 26: 1427-1435.
25. Anna Ratz-Łyko, Jacek Arct. Resveratrol as an active ingredient for cosmetic and dermatological applications: a review. Journal of Cosmetic and Laser Therapy 2019; 21(2): 84-90.
26. Bastianetto S, Dumont Y, Duranton A, Vercauteren F, Breton L,Quirion R. Protective action of resveratrol in human skin: possible involvement of specific receptor binding sites. PLOS One 2010; 5(9): e12935.
27. Potapovich AI, Lulli D, Fidanza P, Kostyuk VA, De Luca C, Pastore S, Korkina LG. Plant polyphenols differentially modulate inflammatory responses of human keratinocytes by interfering with activation of transcription factors NFκB and AhR and EGFR-ERK pathway. Toxicol Appl Pharmacol. 2011; 255: 138-149.
28. Pastore S, Mascia F, Mariani V, Girolomoni G. The epidermal growth factor receptor system in skin repair and inflammation. J Invest Dermatol. 2008;128:1365-1374.
29. Farris P, Yatskayer M, Chen N, Krol Y, Oresajo C. Evaluation of efficacy and tolerance of a nighttime topical antioxidant containing resveratrol, baicalin, and vitamin E for treatment of mild to moderately photodamaged skin. J Drugs Dermatol 2014; 13: 1467-1472.
30. Gonçalves GMS, Barros PP, da Silva GH, dos Santos EM, Minutti AF. Formulations containing curcumin or trans-resveratrol increase dermal thickness in rats submitted to chemical peeling. J Cosmet Dermatol Sci Appl 2017; 7: 14-26.
31. Kanlayavattanakul M, Lourith N. Skin hyperpigmentation treatment using herbs: A review of clinical evidences. J Cosmet Laser Ther 2017; 30: 1-9.
32. Alonso C, Mari M, Barba C, Carrer V, Rubio L, Coderch L. Skin permeation and antioxidant efficacy of topically applied resveratrol. Archives of Dermatological Research 2017; 309. 10.1007/s00403-017-1740-5.
33. Pivetta TP et al. Topical formulation of quercetin encapsulated in natural lipid nanocarriers: Evaluation of biological properties and phototoxic effect. Journal of Drug Delivery Science and Technology 2019; 53: 101148.
34. Chung JH, Seo JY, Choi HR et al. Modulation of skin collagen metabolism in aged and photoaged human skin in vivo. J Investigat Dermatol 2001; 117: 1218-1224.
35. Hatahet T. et al.Quercetin topical application, from conventional dosage forms to nano dosage forms. European Journal of Pharmaceutics and Biopharmaceutics 2016; 108: 41-53.
Published
2020-09-30