A SYSTEMATIC REVIEW OF THE INCIDENCE AND RISK FACTORS FOR HEPATITIS E INFECTION IN ROMANIA
The incidence of viral hepatitis E (HEV) has taken shape in European countries, economically developed areas and with a high level of hygiene. For the occurrence of this disease was initially incriminated the consumption of properly unprocessed pork or travels to endemic areas. Over time, other ways of transmission were discovered. The spread of the virus also included Romania. In this context, we aim to analyze data from the literature on the incidence and risk factors for HEV. Recent studies conducted in Romania have shown a seroprevalence between 9.6% and 50% in farms, highlighting a zoonotic transmission. Another study shown that the risk factors associated with HEV infections were previous blood transfusions, immunosuppressive disorders, or hepatitis B virus co-infection. In conclusion, HVE infection remains an undeclared disease, possible due to misdiagnosis, subclinical infection, or co-infection with another hepatitis virus.
2. Teshale EH, Hu DJ. Hepatitis E: Epidemiology and prevention. World Journal of Hepatology, 2011: 3(12): 285.
3. Ankcorn MJ, Tedder RS. Hepatitis E: the current state of play. Tranfus Med 2017; 27(2): 84-95.
4. Mushahwar IK. Hepatitis E virus: molecular virology, clinical features, diagnosis, transmission, epidemiology, and prevention. Journal of Medical Virology 2008; 80(4): 646-658.
5. Dalton HR, Pas SD, Madden RG, van der Eijk AA. Hepatitis e virus: current concepts and future perspectives. Curr Infect Dis Rep 2014; 16: 399
6. Riveiro-Barciela M, Minguez B, Girones R, Rodriguez-Frias F, Quer J, Buti M. Phylogenetic demonstration of hepatitis E infection transmitted by pork meat ingestion. J Clin Gastroenterol 2015; 49(2): 165-168.
7. ***Hepatitis E: a neglected virus. Editorial. The Lancet Gastroenterology & Hepatology. 2016; 1(4): 261.
8. Hughes JM, Wilson ME, Teshale EH, Hu DJ, Holmberg SD. The two faces of hepatitis E virus. Clinical infectious diseases 2010; 51(3): 328-334.
9. Savuţa G, Aniţă A, Aniţă D, Ludu L, Duca E, Pavio N. Seroepidemiological research regarding swine and human hepatits E in Romania. Lucr St Med Vet USAMVB Timisoara 2008; XLI: 309-313.
10. Anita A, Anita D, Ludu L, Savuta G. Seroepidemiological investigation of human and swine hepatitis in Botosani County. Bull UASVM Vet Med. 2010; 67: 19-22.
11. Voiculescu M, Iliescu L, Ionescu C, Micu L, Ismail G, Zilisteanu D, Radasan A, Micu G, Pertache I. A cross-sectional epidemiological study of HBV, HCV, HDV and HEV prevalence in the SubCarpathian and South-Eastern regions of Romania. J Gastrointestin Liver Dis 2010; 19: 43-48
12. Aniţă A, Gorgan L, Aniţă D, Oşlobanu L, Pavio N, Savuţa G. Evidence of hepatitis E infection in swine and humans in the East Region of Romania. International Journal of Infectious Diseases 2014; 29: 232-237.
13. Aniță AE, et al. Hepatitis E-a new zoonosis present also in Romania. Lucrări Științifice-Medicină Veterinară, Universitatea de Științe Agricole și Medicină Veterinară “Ion Ionescu de la Brad” Iași 2007; 51(10/2): 593-598.
14. Aniță A, et al. Researches regarding the seroprevalence of swine hepatitis E virus infection in the East of Romania. Lucrări Științifice-Medicină Veterinară, Universitatea de Științe Agricole și Medicină Veterinară" Ion Ionescu de la Brad" Iași 2010: 53 (12/2): 219-221.
15. Istrate A, Rădulescu AL. A comparison of hepatitis E and A in a teaching hospital in North-western Romania. Acute hepatitis E–a mild disease? Medicine and Pharmacy Reports 2020; 93(1): 30.
16. Gheorghiță V, Ștefan I, Olaru ID, Radu AM, Săndulescu O, Streinu-Cercel A, Streinu-Cercel A. Seroprevalence and risk factors for hepatitis E virus infection in the Romanian adult population: a cross-sectional study in a tertiary hospital. Revista Romana de Medicină de Laborator 2019; 27(2): 199-208.
17. Mrzljak A, Dinjar-Kujundzic P, Jemersic L, Prpic J, Barbic L, Savic V, Stevanovic V, Vilibic-Cavlek T. Epidemiology of hepatitis E in South-East Europe in the “One Health” concept. World J Gastroenterol 2019; 25(25): 3168-3182.
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