THE IMPACT OF ESBL-PRODUCING ENTEROBACTERALES: AN OLD STORY WITH NEW PERSPECTIVES
Antibiotic resistance represents a global crisis, one of the biggest challenges that humanity is facing. In addition to the SARS-Cov-2 pandemic, we are currently witnessing another, more devastating pandemic of multidrug-resistant micro-organisms, not only in hospitals but also in the community. Material and methods: we aimed to analyze the incidence and implications of urinary isolated, extended-spectrum β-lactamase-producing (ESBL+) Enterobacterales, from patients admitted between 01/01/2018 and 31/12/2018. Results: the main identified pathogen was Escherichia coli, accounting for 67.3% of all cases; the ESBL-production rate was 26.5%, with E. coli and Klebsiella pneumoniae emerging as leading etiologies. Mean age was significantly higher for patients with ESBL+ isolates (57.6 vs. 65.1 years, p<0.0001), while urinary catheterization was more frequently associated with ESBL+ strains (21.8% ESBL+ vs. 6.2% ESBL-, p<0.0001). As anticipated, antibiotic susceptibility was significantly influenced both by ESBL production and urinary catheterization, except for nitrofurantoin and fosfomycin. Conclusions: comprehensive approach of the local antibiotic susceptibility profile can facilitate the choice of a proper therapeutic management, based on regional particularities of an East European country.
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