BREAST CANCER IN WOMEN YOUNGER THAN 35 YEARS OLD: IMMUNOHISTOCHEMICAL AND MOLECULAR CHARACTERISTICS AND IMAGING DIAGNOSIS
The aim of this study was to characterize imaging, immunohistochemical and molecular breast cancer in women younger than 35 years old. Material and methods: In this retrospective study, data were collected from 46 patients under the age of 35, out of a total of 1,854 patients diagnosed with breast cancer between May 2012 and February 2019 at the Regional Institute of Oncology Iasi (Department of Surgery). The following tumor characteristics were evaluated: tumor size, histological type, molecular subtype, histological grade, nodal status and the presence of systemic metastases. Results: Of the 46 cases, invasive ductal carcinoma was the most common histological type (n=31, 67.39%). More than half of the tumors were ER + (n=36, 78.26%) and PR + (n=33, 71.73%). In 84.78% of cases (n=39) we observed a high expression of Ki67 proliferation index (> 20%). Luminal genomic B subtype was the most common (n=27, 58.69%), and triple negative breast cancer was 13.04% (n=6). Conclusions: Breast tumors in young women (under the age of 35) have a much more aggressive tumor biology. Future research is required to investigate new treatment strategies especially in young breast cancer patients.
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