THE PROINFLAMMATORY ROLE OF SERUM IL-6 IN ACUTE OTITIS MEDIA IN CHILDREN
Acute otitis media (AOM) represents the leading cause of health care visits and antibiotic prescriptions in children. In order to reduce the unnecessary antibiotic prescriptions and to avoid the burden of potential complications, new biomarkers may be useful for the diagnosis and follow-up of children with AOM. Material and methods: We performed a prospective study in pediatric patients with AOM hospitalized in a tertiary hospital in Iasi, Romania, during a 1-year period (between November 2021 and November 2022). We assessed the utility of serum interleukin-6, S100A12 protein, ESR (erythrocyte sedimentation rate) and CRP (C-reactive protein) in the diagnosis of children with clinical signs of AOM. Results: A total of 88 children, aged between 2 months old to 17 years old were included (46 with AOM and 42 healthy controls). The differences between the control group and AOM group were statistically significant (p<0.001) for ESR, CRP and IL-6 (median values being much higher in the case of patients with AOM). The differences between the control group and the one with AOM were only random (p=0.326 > 0.05) in case of S100A12 protein. ESR > 27 mm/hour was associated with a 2 times higher risk (RR=2.022) of having concomitant adenoiditis. Conclusions: IL-6 could offer a powerful tool for the objective evaluation of AOM. Further research is needed to fully elucidate the role of IL-6 in AOM and to determine whether it may be a useful biomarker for predicting treatment outcomes.
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