• Alice Nicoleta AZOICAI “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Ileana Katerina IONIUC “Sf. Maria'” Emergency Clinical Hospital for Children, Iasi


Urticaria is considered a multifactorial condition, initializing or triggering chronic conditions with dermal or/and hypodermic localization, more common in children and young people. Material and methods: A number of 87 children were considered in a retrospective study aiming the diagnostic of acute and chronic urticaria, evolutive particularities and immunological aspects of the allergic condition. Descriptive analysis and correlation with biological parameters of the immunological status (total IgE, allergen-specific Ig E IgA, IgM, IgG) were performed. Results: The age distribution showed that most children aged 10-15, with a balanced gender distribution (59.57% male vs. 40.43% female patients). Immunological profile associated immune deficiency (IgA and IgG, a minority of patients presenting deficiency of IgM). Elevation of IgE values were found in 9% of cases. Low serum levels of Ig G, A, and M associated clinical features such as upper respiratory infection, gastroenteritis, and otitis media. Four patients with multiple immunoglobulin deficiency and 5 cases with single immunoglobulin deficiency were noticed, including a complete IgA deficiency. Arthritic impairment was observed in 10% of cases. Conclusions: Various immune deficiencies were found in children with acute and chronic urticaria. Prospective research is needed to clarify the real role of triggers in the pathogenesis of urticaria and their relative prevalence, in order to apply, with greater accuracy, prevention methods in children at risk.

Author Biographies

Alice Nicoleta AZOICAI, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Faculty of Medicine
Department of Maternal and Child Medicine

Ileana Katerina IONIUC, “Sf. Maria'” Emergency Clinical Hospital for Children, Iasi

IInd Pediatric Clinic


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