• C. PRICOP “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • D. PUIA “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • I. CHIRIAC “Dr. C. I. Parhon” Clinical Hospital, Iasi, Romania
  • Adelina MIRON “Grigore T. Popa” University of Medicine and Pharmacy Iasi


In order to customize the follow-up plan and lower the risks of end-stage renal disease progression (ESRD), we set out to create a monitoring program for patients with surgical solitary kidneys. Additionally, by determining the underlying etiology and comorbidities (such as pre-existing CKD or Diabetes). 91 patients have been found who satisfy the inclusion requirements. Material and methods: There were 51 ladies and 40 guys among them. They ranged in age from 20 to 90. The average age was 60.69 years (SD +/- 15.87). There was no difference in the mean age between the genders (63.22 vs. 58.71, p=0.08). Kidney cancer (50.54%), upper urothelial tract carcinoma (25.27%), pyonephrosis (17.58%), and kidney trauma (6.59%) were the primary pathologies for which surgery was performed. The patients were also arbitrarily separated into three age groups: Group A, 20-40 years old; Group B, 41-60 years old; and Group C, over 60 years old. Results: One month after discharge, C-reactive protein increased (p=0.05), and eGFR decreased significantly (p=0.003). The most common comorbidity (74.72%; n=68) was arterial hypertension. Of these, 51.47% (n=35) have diabetes mellitus concurrently. Diabetes was the second-highest occurrence, with 49.45% (n=45) of patients receiving therapy for it. Also, at the time of surgery, 12.08 % (n=11) had CKD, according to KDIGO definition. Since acquired solitary kidney patients are more likely to experience rapidly declining renal function, they require continuous monitoring. Conclusions: Younger individuals are more prone to develop CKD slowly. Therefore, the clinician has to monitor issues like kidney stones or urinary tract infections.

Author Biographies

C. PRICOP, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Faculty of Medicine
Department of Surgery (II)

D. PUIA, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Faculty of Medicine
Department of Surgery (II)

I. CHIRIAC, “Dr. C. I. Parhon” Clinical Hospital, Iasi, Romania

Clinic of Urology and Kidney Transplantation

Adelina MIRON, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Faculty of Medicine
Department of Surgery (II)


1. Brenner BM. Nephron adaptation to renal injury or ablation. Am J Physiol 1985; 249(3Pt 2): F324-337.
2. Sanna-Cherchi S, Ravani P, Corbani V, et al. Renal outcome in patients with congenital anomalies of the kidney and urinary tract. Kidney Int 2009; 76(5): 528-533.
3. Kim S, Chang Y, Lee YR, et al. Solitary kidney and risk of chronic kidney disease. Eur J Epidemiol 2019; 34(9): 879-888.
4. Groen In’t Woud S, Roeleveld N, Westland R, et al. Uncovering risk factors for kidney injury in children with a solitary functioning kidney. Kidney Int 2023; 103(1): 156-165.
5. Argueso LR, Ritchey ML, Boyle ET Jr, Milliner DS, Bergstralh EJ, Kramer SA. Prognosis of patients with unilateral renal agenesis. Pediatr Nephrol 1992; 6(5): 412-416.
6. Xu Q, Wu H, Zhou L, et al. The clinical characteristics of Chinese patients with unilateral renal agen-esis. Clin Exp Nephrol 2019; 23(6): 792-798.
7. Worcester E, Parks JH, Josephson MA, Thisted RA, Coe FL. Causes and consequences of kidney loss in patients with nephrolithiasis. Kidney Int 2003; 64(6): 2204-2213.
8. Pricop C, Ivănuţă M, Stan A, et al. Correlations between stones composition, dietary and comorbidities context of the lithiasic patient. Rom J Morphol Embryol 2020; 61(4): 1227-1233.
9. Kiberd M, Panek R, Kiberd BA New onset diabetes mellitus post-kidney transplantation. Clinical Transplantation 2006; 20(5): 634-639.
10. Alfandary H, Haskin O, Goldberg O, et al. Is the prognosis of congenital single functioning kidney benign? A population-based study. Pediatr Nephrol 2021; 36(9): 2837-2845.
11. Ellis RJ. Chronic kidney disease after nephrectomy: a clinically-significant entity? Transl Androl Urol 2019; 8(Suppl 2): S166-S174.
12. Pricop C, Ivănuta M, Puia D. Active metabolic lithiasis: A condition that requires proper evaluation and monitoring. Exp Ther Med 2022; 24(6): 715.
13. Puia D, Radavoi GD, Proca TM, Puia A, Jinga V, Pricop C. Urinary tract infections in complicated kidney stones: Can they be correlated with Guy's stone score? J Pak Med Assoc 2022; 72(9): 1721-1725.
14. Pricop C, Puia D, Mereuta O, et al. Infected hydronephrosis: can we reduce patient suffering and costs? J Pak Med Assoc 2016; 66(11): 1372-1377.
15. Naqvi SB, Collins AJ. Infectious complications in chronic kidney disease. Adv Chronic Kidney Dis 2006; 13(3): 199-204.
16. Shang W, Li L, Ren Y, et al. History of kidney stones and risk of chronic kidney disease: a meta-analysis. Peer J 2017; 5: e2907.
17. Demirjian S, Lane BR, Derweesh IH, et al. Chronic kidney disease due to surgical removal of neph-rons: relative rates of progression and survival. J Urol 2014; 192: 1057-1062.
18. Kidney Disease: Improving Global Outcomes CKD Workgroup. KDIGO 2012 clinical practice guide-line for the evaluation and management of chronic kidney disease. Kidney Int Suppl 2013; 3:1-150.