RENAL FUNCTION DYNAMICS IN PATIENTS WITH RADICAL PROSTATECTOMY FOR PROSTATIC ADENOCARCINOMA
Abstract
Renal function parameters, readily assessed through routine blood tests, have been largely unexplored in relation to prostate cancer. This study aims to investigate the associations between renal function parameters (creatinine, urea, estimated glomerular filtration rate-eGFR), both pre- and post- prostatectomy, and histopathological characteristics of prostate adenocarcinomas. Additionally, it evaluates potential correlations with prostate biochemical recurrence, offering insights into kidney function dynamics post-prostatectomy. Material and methods: We analyzed data from 72 patients with prostate adenocarcinoma who underwent radical prostatectomy. Histopathological reevaluation was conducted, including Gleason score, pT stage, prognostic grade groups, and biochemical recurrence assessment. Preoperative and postoperative renal parameters were recorded, and eGFR was calculated using the CKD-EPI formula. Statistical analysis was performed to assess associations. Results: Preoperative eGFR showed a significant association with Gleason score and prognostic grade groups (p<0.05). However, there were no significant correlations between renal parameters and biochemical recurrence or pT stage. Conclusions: This study emphasizes the potential utility of eGFR as a marker for identifying prostate adenocarcinomas with higher Gleason scores and prognostic grade groups. While the complexity of renal function dynamics in prostate cancer warrants further investigation, our findings contribute to understanding the intricate relationship between kidney function and prostate tumor behavior.
References
2. Gandaglia G, Leni R, Bray F, et al. Epidemiology and prevention of prostate cancer. Eur Urol Oncol 2021; 4(6): 877-892.
3. Alizadeh M, Alizadeh S. Survey of clinical and pathological characteristics and outcomes of patients with prostate cancer. Glob J Health Sci 2014; 6: 49-57.
4. Ilic D, Djulbegovic M, Jung JH, et al. Prostate cancer screening with prostate-specific antigen (PSA) test: a systematic review and meta-analysis. BMJ 2018; 362: k3519.
5. Modi PK, Eggener SE. Prostate-specific antigen to predict early success of focal therapy: focusing on appropriate endpoints. Eur Urol 2020; 78(2): 161-162.
6. Chung JH, Jeong JY, Lee JY, et al. Biochemical recurrence after radical prostatectomy according to nadir prostate specific antigen value. PLoS One 2021; 16(5):e0249709.
7. Kaffenberger SD, Barbieri CE. Molecular subtyping of prostate cancer. Curr Opin Urol 2016; 26(3): 213-218.
8. Orozco Scott P, Deshpande P, Abramson M. Genitourinary cancer: updates on treatments and their impact on the kidney. Semin Nephrol 2022; 42(6): 151344.
9. Gu X, Wu J, Liu X, Hong Y, Wu Y, Tian Y. Role of serum creatinine levels in prognostic risk stratification of prostate cancer patients. Med Sci Monit 2022; 28: e937100.
10. Wang M, Zou L, Liang J, et al. The urinary sarcosine/creatinine ratio is a potential diagnostic and prognostic marker in prostate cancer. Med Sci Monit 2018; 24: 3034-3041.
11. WHO Classification of Tumours Editorial Board. Urinary and Male Genital Tumours. WHO Classification of Tumours, 5th ed., vol. 8, IARC Press: Lyon, France, 2022.
12. Meeusen JW, Kasozi RN, Larson TS, Lieske JC. Clinical impact of the refit CKD-EPI 2021 creatinine-based eGFR equation. Clin Chem 2022; 68(4): 534-539.
13. Sherer MV, Deka R, Salans MA, Nelson TJ, Sheridan P, Rose BS. Androgen deprivation therapy and acute kidney injury in patients with prostate cancer undergoing definitive radiotherapy. Prostate Cancer Prostatic Dis 2023; 26(2): 276-281.
14. Masuda H, Fujimoto A, Kanesaka M, et al. Renal function improves after the discontinuation of androgen deprivation therapy in Japanese patients with prostate cancer. Anticancer Res 2021; 41(9): 4443-4446.
15. Miyazawa Y, Sekine Y, Arai S, Nomura M, Koike H, Matsui H, Suzuki K. Changes in renal function of patients with prostate cancer: focus on androgen deprivation therapy. Cancer Diagn Progn 2022; 2(6): 686-690.
16. Benli E, Cirakoglu A, Ayyıldız SN, Yüce A. Comparison of serum uric acid levels between prostate cancer patients and a control group. Cent European J Urol 2018; 71(2): 242-247.
17. Li R, Tang H, Bao T, Yang H, Jin T. Correlation between prostate-specific antigen and four renal function-associated parameters in different ethnicities in southwest China. Exp Ther Med 2020; 20(6): 143 / doi: 10.3892/etm.2020.9272.
18. Tollefson MK, Boorjian SA, Gettman MT, Rangel LJ, Bergstralh EJ, Karnes RJ. Preoperative estimated glomerular filtration rate predicts overall mortality in patients undergoing radical prostatectomy. Urol Oncol 2013; 31(8): 1483-1488.
COPYRIGHT
Once an article is accepted for publication, MSJ requests a transfer of copyrights for published articles.
COPYRIGHT TRANSFER FORM FOR
REVISTA MEDICO-CHIRURGICALĂ A SOCIETĂȚII DE MEDICI ȘI NATURALIȘTI DIN IAȘI /
THE MEDICAL-SURGICAL JOURNAL OF THE SOCIETY OF PHYSICIANS AND NATURALISTS FROM IASI
We, the undersigned authors of the manuscript entitled
_____________________________________________________________________________________
_____________________________________________________________________________________
warrant that this manuscript, which is submitted for publication in the REVISTA MEDICO-CHIRURGICALĂ, has not been published and it is not under consideration for publication in another journal.
- we give the consent for publication in the REVISTA MEDICO-CHIRURGICALĂ, in printed and electronic format and we transfer unconditioned and complete the copyright of this manuscript to the REVISTA MEDICO-CHIRURGICALĂ, in the event of its acceptance.
- the manuscript does not break the intellectual property rights of any other person.
- we have read the submitted version of the manuscript and we are fully responsible for the content.
Names and signatures of authors / copyright owners (the following sequence is the authorship of the article):
- ______________________________/_________________________
- ______________________________/_________________________
- ______________________________/_________________________
N.B. All the authors must sign this form
