THE PROGNOSTIC VALUE OF CEA AND CA 19-9 IN DETERMINING SURVIVAL OUTCOMES FOR PATIENT WITH LOW RECTAL CANCER

  • C.C. VOLOVAT “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • D.V. SCRIPCARIU “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Diana BOBOC “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Simona-Ruxandra VOLOVAT “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Ingrid-Andrada VASILACHE “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Corina LUPASCU-URSULESCU “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Liliana GHEORGHE “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Luiza-Maria BAEAN “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • C. VOLOVAT “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • V. SCRIPCARIU “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Abstract

The prognostic value of carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9) is a topic of interest for surgeons. The aim of this retrospective study was to evaluate the prognostic value of CEA and CA 19-9 in patients with locally advanced low rectal cancer who underwent neoadjuvant chemoradiotherapy, underlining their potential as indicators for survival outcomes. Materials and methods: Between November 2019 and February 2023, we evaluated the medical records of 104 patients admitted to the first Oncologic Surgical Clinic from the Regional Institute of Oncology, Iasi, Romania. Clinical and paraclinical data was recorded, and patients were segregated intro three groups: one marker elevated during follow-up (group 1), 2 markers elevated during follow-up (group 2), and no marker elevated during follow-up (group 3). The overall survival and recurrence-free survival were the evaluated outcomes, and the prognostic values of serum markers were evaluated using Cox regression model and Kaplan-Meyer survival analysis. (3) Results: The presence of one (hazard ratio, HR: 2.78, 95% confidence interval, CI: 1.11- 6.92, p= 0.02) or both (HR: 4.23, 95%CI: 1.44- 9.32, p=0.03) elevated markers statistically decreased the recurrence-free survival time. A combination of elevated markers has a significantly higher impact on the recurrence-free survival time compared to a single elevated marker (p=0.001). Only the combination of biomarkers significantly decreased the overall survival rates (HR: 3.74, 95% CI: 0.57- 7.62, p= 0.04). (4) Conclusions: The combination of elevated CEA and CA 19-9 had the highest prognostic significance for the evaluated survival outcomes.

Author Biographies

C.C. VOLOVAT, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Faculty of Medicine
Department of Surgery (II) / Radiology

D.V. SCRIPCARIU, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Faculty of Medicine
Department of Surgery (I)

Diana BOBOC, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Faculty of Medicine
Department of Medical Specialties (III) / Oncology / Radiotherapy

Simona-Ruxandra VOLOVAT, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Faculty of Medicine
Department of Medical Specialties (III) / Oncology / Radiotherapy

Ingrid-Andrada VASILACHE, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Faculty of Medicine
Department of Mother and Child Medicine

Corina LUPASCU-URSULESCU, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Faculty of Medicine
Department of Surgery (II) / Radiology

Liliana GHEORGHE, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Faculty of Medicine
Department of Surgery (II) / Radiology

Luiza-Maria BAEAN, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Faculty of Medicine
Department of Surgery (II) / Radiology

C. VOLOVAT, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Faculty of Medicine
Department of Medical Specialties (III) / Oncology / Radiotherapy

V. SCRIPCARIU, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Faculty of Medicine
Department of Surgery (I)

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Published
2024-03-29