CHITOSAN-GELATINMICRO/NANOPARTICLES AS A CONTROLLED DELIVERY OF DEXKETOPROFEN TROMETAMOL FOR TOPICAL APPLICATIONS IN WOUND CARE

Authors

  • T. BIBIRE Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • R. DANILA Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Corina-Lenuța LOGIGAN “Gheorghe Asachi” Technical University of Iasi, Romania
  • Catalina Anisoara PEPTU “Gheorghe Asachi” Technical University of Iasi, Romania
  • R.S. COZMA Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Cristina Mihaela GHICIUC Grigore T. Popa” University of Medicine and Pharmacy Iasi

DOI:

https://doi.org/10.22551/MSJ.2024.02.21

Abstract

Progress in the nanotechnology field has led to the discovery of various drug delivery systems for biomedical applications in the last few decades. Materials and methods: Micro/nanoparticles (MPs) based on chitosan (CS) and gelatin (GEL), designed as a drug delivery system for biomedical applications, were prepared using a double cross-linking process within an emulsion-phase separation system. Results: The obtained MPs were characterized using scanning electron microscopy (SEM), which revealed diameters ranging from 0.467 to 4.596 µm. The swelling properties of the MPs were investigated in a neutral environment with a pH of 5.5. Conclusions: The applicability of the prepared materials was further evaluated for drug loading and in vitro delivery of Dexketoprofen trometamol (DEX), demonstrating excellent capacity, which recommends them for effective wound care, including postoperative wounds.

Author Biographies

  • T. BIBIRE, Grigore T. Popa” University of Medicine and Pharmacy Iasi

    Faculty of Medicine
    Ph.D. Student, Doctoral School
    “Sf. Spiridon” County Clinical Emergency Hospital, Iasi, Romania

  • R. DANILA, Grigore T. Popa” University of Medicine and Pharmacy Iasi

    Faculty of Medicine
    Department of Surgery (I)
    “Sf. Spiridon” County Clinical Emergency Hospital, Iasi, Romania

  • Corina-Lenuța LOGIGAN, “Gheorghe Asachi” Technical University of Iasi, Romania

    Faculty of Chemical Engineering and Environmental Protection “Cristofor Simionescu”
    Department of Natural and Synthetic Polymers

  • Catalina Anisoara PEPTU, “Gheorghe Asachi” Technical University of Iasi, Romania

    Faculty of Chemical Engineering and Environmental Protection “Cristofor Simionescu”
    Department of Natural and Synthetic Polymers

  • R.S. COZMA, Grigore T. Popa” University of Medicine and Pharmacy Iasi

    Faculty of Medicine
    Department of Surgery (II)
    Clinical Recovery Hospital, Iasi, Romania

  • Cristina Mihaela GHICIUC, Grigore T. Popa” University of Medicine and Pharmacy Iasi

    Faculty of Medicine
    Department of Morpho-Functional Sciences (II)
    “Sf. Maria” Clinical Hospital for Children, Iasi, Romania

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Additional Files

Published

2024-06-28

Issue

Vol. 128 No. 2 (2024): The Medical-Surgical Journal

Section

PHARMACY

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