DESIGN, CHARACTERIZATION AND BIOCOMPATIBILITY EVALUATION OF POLYMERIC NETWORKS AS CARRIERS FOR INDOMETHACIN MODIFIED RELEASE

Authors

  • Angy Abu KOUSH Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Ana-Maria Raluca PĂUNA Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Ruxandra Teodora STAN Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • D. A. CHIRAN Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Irina-Luciana GURZU Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Liliana Lăcrămioara PAVEL Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • C. I. STAN Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Liliana MITITELU-TARTAU Grigore T. Popa” University of Medicine and Pharmacy Iasi

Abstract

Pharmaceutical nanotechnology's progression expands drug versatility, utilizing carrier systems to efficiently deliver active ingredients to targeted tissues for controlled release within effective concentrations. Integrating nonsteroidal anti-inflammatory drugs (NSAIDs) into nano-systems holds potential for enhancing pharmacokinetic properties and diminishing adverse effects. Aim: Our study concentrated on formulating nanoparticles embedding indomethacin (IND), characterizing them, exploring drug release dynamics, and assessing their biocompatibility in rats. Materials and methods: IND was loaded within copolymeric networks comprising poly(2-hydroxyethyl methacrylate-co-3,9-divinyl-2,4,8,10-tetraoxaspiro [5.5]-undecane) and poly(aspartic acid) (PAS) as a protective colloid, employing a dispersion polymerization approach. Fourier transform infrared spectroscopy (FT-IR) characterized the copolymeric matrices, and spectrophotometric analysis via dissolution method evaluated in vitro IND release. In vivo biocompatibility was gauged by monitoring hematological, biochemical, and immune parameters in rats. Results: Our developed nano-systems effectively loaded IND within polymeric matrices. The kinetics of IND release were influenced by copolymer composition, with lower comonomer concentrations extending release duration. The investigated copolymer networks incorporating IND did not elicit significant hematological, biochemical, or immune changes when administered to rats. Conclusions: the studied polymer samples exhibited promising in vivo biocompatibility, positioning them as potential candidates for IND modified-release systems with prospective biomedical applications.

Author Biographies

  • Angy Abu KOUSH, Grigore T. Popa” University of Medicine and Pharmacy Iasi

    Faculty of Medicine
    Ph.D. Student

  • Ana-Maria Raluca PĂUNA, Grigore T. Popa” University of Medicine and Pharmacy Iasi

    Faculty of Medicine
    Department of Morpho-Functional Sciences (I)

  • Ruxandra Teodora STAN, Grigore T. Popa” University of Medicine and Pharmacy Iasi

    Faculty of Medicine
    Department of Preventive Medicine and Interdisciplinarity

  • D. A. CHIRAN, Grigore T. Popa” University of Medicine and Pharmacy Iasi

    Faculty of Medicine
    Department of Morpho-Functional Sciences (I)

  • Irina-Luciana GURZU, Grigore T. Popa” University of Medicine and Pharmacy Iasi

    Faculty of Medicine
    Department of Preventive Medicine and Interdisciplinarity

  • Liliana Lăcrămioara PAVEL, Grigore T. Popa” University of Medicine and Pharmacy Iasi

    Faculty of Dental Medicine
    Medical Student

  • C. I. STAN, Grigore T. Popa” University of Medicine and Pharmacy Iasi

    Faculty of Medicine
    Department of Morpho-Functional Sciences (I)

  • Liliana MITITELU-TARTAU, Grigore T. Popa” University of Medicine and Pharmacy Iasi

    Faculty of Medicine
    Department of Morpho-Functional Sciences (II)

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Additional Files

Published

2024-09-18