RECURRENT RHABDOMYOLYSIS IN CHILDREN: A “RED FLAG” FOR UNDERLYING METABOLIC MYOPATHY AND THE NEED FOR NATIONAL PEDIATRIC VIGILANCE

Authors

  • Tania-Elena RUSU Regina Maria Healthcare Campus, Iasi, Romania
  • Ingith MIRON Professor of Pediatrics
  • Paula POPOVICI Grigore T. Popa University of Medicine and Pharmacy Iasi

DOI:

https://doi.org/10.22551/MSJ.2025.04.01

Keywords:

RECURRENT RHABDOMYOLYSIS IN CHILDREN, “RED FLAG” FOR UNDERLYING METABOLIC MYOPATHY

Abstract

Recurrent rhabdomyolysis in children is a diagnostic “red flag” for underlying metabolic or genetic disease. Early recognition, comprehensive investigation, and preventive strategies can significantly reduce morbidity and mortality. Romania currently lacks pediatric data, registries, and structured diagnostic pathways. Establishing these resources will position national centers - particularly those in Iași - as leaders in pediatric metabolic medicine.

References

1. Elsayed EF, Reilly RF. Rhabdomyolysis: a review, with emphasis on the pediatric population. Pediatr Nephrol 2010; 25(1): 7-18.

2. Yazıcı H, Kalkan Uçar S. A metabolism perspective on pediatric rhabdomyolysis. Trends Pediatr 2021; 2(4): 147-153.

3. Chen R, Wang C, Zheng B, et al. A rare case of pediatric recurrent rhabdomyolysis with compound heterogenous variants in LPIN1. BMC Pediatr 2020; 20: 218.

4. Ghioacă C. 75% dintre pacienţii români cu boli rare sunt copii. Viaţa Medicală. 2025 /

www.viata-medicala.ro/75-dintre-pacientii-romani-cu-boli-rare-sunt-copii-40935

5. Alves A, et al. Rhabdomyolysis in children: a state-of-the-art review. Children 2025; 12(4): 492.

6. Zaki HA, Elmelliti H, Malik WA, et al. Pediatric rhabdomyolysis: a systematic review and a meta- analysis of etiologies, management, and outcomes. BMC Pediatr 2025; 25: 866.

7. Topal S, Köse MD, Ağın H, et al. A neglected cause of recurrent rhabdomyolysis: LPIN1 gene defect. Turk J Pediatr 2020; 62(4): 647-651.

8. Scalco RS, Gardiner AR, Pitceathly RD, et al. Rhabdomyolysis: a genetic perspective. Orphanet J Rare Dis 2015; 10: 51.

9. Cabrera-Serrano M, Ravenscroft G. Recent advances in our understanding of genetic rhabdomyolysis. Curr Opin Neurol 2022; 35(5): 651-657.

10. Kruijt N, van de Camp SAJH, Kramer JJ, et al. Rhabdomyolysis in the era of next-generation se-quencing: selecting patients with a high likelihood of genetic susceptibility using ‘RHABDO’ features. Genes 2025; 16(9): 995.

11. Bădeanu I, Popescu A. Rabdomioliza la sportivi: fiziopatologie şi management. Rev Galenus 2022 /

www.revistagalenus.ro/practica-medicala/rabdomioliza-la-sportivi-fiziopatologie-si-management

12. Dima V. Newborn Screening in Romania - Present and Future. Rom J Prev Med. 2022; 1(1): 20-26.

Additional Files

Published

2025-12-19

Issue

Vol. 129 No. 4 (2025): The Medical-Surgical Journal

Section

EDITORIAL

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