DETERMINATION OF HEART RATE VARIABILITY, A POSSIBLE MARKER FOR ASSESSING INTRINSIC CAPACITY
DOI:
https://doi.org/10.22551/MSJ.2025.04.05Abstract
The assessment of heart rate variability (HRV) parameters is a non-invasive method of multidimensional evaluation of geriatric patients, independent of complex geriatric and clinical-biological assessment, with an impact on the early identification of nutritional disorder, cognitive status, psycho-emotional status, frailty, cardiovascular mortality risk, as well as functional disorders and maintaining quality of life. Aim: To determine HRV parameters and their role in assessing intrinsic capacity in old patients. Materials and methods: We determined HRV in a group of 83 patients over the age of 65 who were admitted to the Geriatric Clinic of the Dr. C. I. Parhon Hospital in Iasi, and we also performed a complex geriatric assessment by evaluating cognitive status (MMSE - Mini-Mental State Exam), nutritional status (MNA - Mini Nutritional Assessment), psycho-emotional (GDS - Geriatric Depression Scale), risk of falling (Downton Scale), the presence or the absence of the urinary incontinence, as well as determining body composition using bioimpedance. Results: The average age was 75.64 ± 6.64 years with a median of 75 years, most patients being women (63.9%). The distribution by age group shows that most patients were between 65 and 74 years old (48.2%), falling into the young old category; of these, 60% were female. Low scores on the MNA, as well as low muscle strength, body mass index, bone mass, visceral fat values or urinary incontinence are correlated with decreased heart rate variability (HRV) parameters. The presence of anemia or depressive symptoms is associated with reduced levels of HRV parameters. Conclusions: Data obtained support the existence of a causal relationship between heart rate variability (HRV) and a number of factors, both dependent on the patient’s clinical-biological status and geriatric profile, and independent of it. Early identification of these factors in the old population is essential for preventing adverse changes in body composition, appearance in psycho-emotional disorder, urinary incontinence, as well as for mitigating their impact on autonomy and quality of life.
References
1. Vanderlei LC, Pastre CM, Hoshi RA, Carvalho TD, Godoy MF. Basic notions of heart rate variability and its clinical applicability. Rev Bras Cir Cardiovasc 2009; 24(2): 205-217 / doi: 10.1590/s0102-76382009000200018.
2. Turcu AM, Ilie AC, Ștefăniu R, et al. The Impact of Heart Rate Variability Monitoring on Preventing Severe Cardiovascular Events. Diagnostics (Basel) 2023; 13(14): 2382 / doi: 10.3390/diagnostics13142382.
3. World Health Organization ICOPE - Integrated Care for Older People, ISBN: 9789241550109
4. Zhang D, Wang W, Li F. Association between resting heart rate and coronary artery disease, stroke, sudden death and non-cardiovascular diseases: a meta-analysis. CMAJ 2016; 188(15): E384-E392 / doi: 10.1503/cmaj.160050.
5. Goldenberg I, Goldkorn R, Shlomo N, et al. Heart Rate Variability for Risk Assessment of Myocardial Ischemia in Patients Without Known Coronary Artery Disease: The HRV-DETECT (Heart Rate Variability for the Detection of Myocardial Ischemia) Study. J Am Heart Assoc 2019; 8(24): e014540 / doi: 10.1161/ JAHA. 119.014540.
6. Hartmann R, Schmidt FM, Sander C, Hegerl U. Heart Rate Variability as Indicator of Clinical State in Depression. Front Psychiatry 2019; 9: 735 / doi: 10.3389/fpsyt. 2018.00735.
7. Arantes FS, Rosa Oliveira V, Leão AKM, et al. Heart rate variability: A biomarker of frailty in older adults? Front Med (Lausanne) 2022; 9: 1008970 / doi: 10.3389/ fmed.2022.1008970.
8. Toosizadeh N, Ehsani H, Parthasarathy S, et al. Frailty and heart response to physical activity. Arch Gerontol Geriatr 2021; 93: 104323 / doi: 10.1016/j.archger.2020.104323.
9. Bauer A, Barthel P, Schneider R, et al. Improved Stratification of Autonomic Regulation for risk prediction in post-infarction patients with preserved left ventricular function (ISAR-Risk). Eur Heart J 2009; 30: 576-583 / doi: 10.1093/eurheartj/ehn540
10. Ogliari G, Mahinrad S, Stott DJ, et al. Resting heart rate, heart rate variability and functional decline in old age. CMAJ 2015; 187(15): E442-E449 / doi: 10.1503 /cmaj. 150462.
11. Fox K, Borer JS, Camm AJ, Danchin N, et al. Heart Rate Working Group. Resting heart rate in cardiovascular disease. J Am Coll Cardiol 2007; 50(9): 823-830 / doi: 10.1016/j.jacc.2007. 04.079.
12. Chaves PH, Varadhan R, Lipsitz LA, et al. Physiological complexity underlying heart rate dynamics and frailty status in community-dwelling older women. J Am Geriatr Soc 2008; 56(9): 1698-703 / doi: 10.1111/j.1532-5415.2008.01858.x.
13. Kim JA, Park YG, Cho KH, et al. Heart rate variability and obesity indices: emphasis on the response to noise and standing. J Am Board Fam Pract 2005; 18: 97-103.
14. Sinha MK, Maiya GA, Moga AM, et al Exercise dose-response relationship with heart rate variability in individuals with overweight and obesity: protocol for a systematic review and meta-analysis of randomized controlled trials. BMJ Open 2022; 12(4): e047821.
15. Mouridsen MR, Bendsen NT, Astrup A, et al. Modest weight loss in moderately overweight postmenopausal women improves heart rate variability. Eur J Prev Cardiol 2013; 20: 671-677.
16. Young HA, Benton D. Heart-rate variability: a biomarker to study the influence of nutrition on physiological and psychological health? Behav Pharmacol 2018; 29(2 and 3-Special Issue): 140-151 / doi: 10.1097/FBP.0000000000000383.
17. Hayley A. Young, David Benton. Heart-rate variability: a biomarker to study the influence of nutrition on physiological and psychological health? Behav Pharmacol 2018; (2 and 3-Spec Issue): 140-151.
18. Struven A, Holzapfel C, Stremmel C, Stefan Brunner S. Obesity, Nutrition and Heart Rate Variability. International Journal of Molecular Sciences 2021; 22(8): 4215.
19. Hassya IA, Sahroni A, Rahayu AW, Laksono ED. The analysis of heart rate variability properties and body mass index in representing health quality information. Procedia Computer Science 2022; 197: 135-142.
20. Kuang D, Liqian C, Kuang S, et al. Effect of gender-related depression on heart rate variability during an autonomic nervous test. Psychiatry research 2019; 272: 258-264
21. Deng Y, Sato N. Global frailty screening tools: Review and application of frailty screening tools from 2001 to 2023. Intractable Rare Dis Res 2024; 13: 1-11 / doi: 10.5582/irdr.2023.01 113.
22. Pashmdarfard M, Azad A. Assessment tools to evaluate Activities of Daily Living (ADL) and Instrumental Activities of Daily Living (IADL) in older adults: A systematic review. Med J Islam Repub Iran 2020; 34: 33 / doi: 10.47176/mjiri.34.33.
23. Vaishya R, Misra A, Vaish A, Ursino N, D’Ambrosi R. Hand grip strength as a proposed new vital sign of health: A narrative review of evidences. J. Health Popul Nutr 2024; 43: 7 / doi: 10.1186/s41043-024-00500-y.
24. Arevalo-Rodriguez I, Smailagic N, Roqué-Figuls M, et al. Mini-Mental State Examination (MMSE) for the early detection of dementia in people with mild cognitive impairment (MCI) Cochrane Database Syst Rev 2021; 7: CD010783 / doi: 10.1002/14651858.CD010783.pub3.
25. Calvo I, Olivar J, Martinez E, Díaz J, Gimena M. MNA Mini Nutritional Assessment as a nutritional screening tool for hospitalized older adults; rationales and feasibility. Nutr Hosp 2012; 27: 1619-1625.
26. Sherry A, Greenberg, The Geriatric Depression Scale (GDS) Issue #4 of General Assessment Series. (accessed on 15 April 2025). Available online: https:// hign.org/consultgeri/try-this-series/geriatric-depression-scale-gds.
27. Ardura JA. Autonomic nervous system regulation of bone metabolism: An updated review. Frontiers in Endocrinology 2018; 9, 230 / doi: 10.3389/fendo.2018.00230.
28. Buchman AS, et al Heart rate variability and physical function in older adults. Circulation 2007; 115(6): 654-660 / doi: 10.1161/CIRCULATIONAHA.106.651 145.
Additional Files
Published
Issue
Section
License
Copyright (c) 2025 The Medical-Surgical Journal

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
COPYRIGHT
Once an article is accepted for publication, MSJ requests a transfer of copyrights for published articles.
COPYRIGHT TRANSFER FORM FOR
REVISTA MEDICO-CHIRURGICALĂ A SOCIETĂȚII DE MEDICI ȘI NATURALIȘTI DIN IAȘI /
THE MEDICAL-SURGICAL JOURNAL OF THE SOCIETY OF PHYSICIANS AND NATURALISTS FROM IASI
We, the undersigned authors of the manuscript entitled
_____________________________________________________________________________________
_____________________________________________________________________________________
warrant that this manuscript, which is submitted for publication in the REVISTA MEDICO-CHIRURGICALĂ, has not been published and it is not under consideration for publication in another journal.
- we give the consent for publication in the REVISTA MEDICO-CHIRURGICALĂ, in printed and electronic format and we transfer unconditioned and complete the copyright of this manuscript to the REVISTA MEDICO-CHIRURGICALĂ, in the event of its acceptance.
- the manuscript does not break the intellectual property rights of any other person.
- we have read the submitted version of the manuscript and we are fully responsible for the content.
Names and signatures of authors / copyright owners (the following sequence is the authorship of the article):
- ______________________________/_________________________
- ______________________________/_________________________
- ______________________________/_________________________
N.B. All the authors must sign this form