ASSOCIATION BETW1EEN LIFESTYLE FACTORS AND OSTEOPOROSIS: A CROSS-SECTIONAL STUDY IN A ROMANIAN POPULATION
DOI:
https://doi.org/10.22551/MSJ.2026.02.16Abstract
Osteoporosis is a major public health problem characterized by reduced bone mass and increased fracture risk. Lifestyle factors play an important role in its development and prevention. This study examines the relationship between lifestyle factors and osteoporosis in an adult Romanian population, providing recommendations for prevention through adequate calcium and vitamin D intake and the promotion of a healthy lifestyle. Aim: To evaluate the association between lifestyle habits and the presence of osteoporosis. Materials and methods: A cross-sectional study was conducted on 160 participants using an online questionnaire. Variables analyzed included age, sex, BMI, smoking status, physical activity, and supplement use. Statistical analysis was performed using chi-square tests, point-biserial correlations, and multivariate logistic regression (p<0.05). Results: The prevalence of osteoporosis was 13.12%. Age was the only factor significantly associated with osteoporosis (r=0.453; p < 0.001) and remained an independent predictor in logistic regression (OR=1.15; 95% CI: 1.08-1.21; p<0.001). No significant associations were found for sex (p=0.19), BMI, smoking, or physical activity (p>0.05). Supplement use was statistically significant (p<0.001), but likely influenced by reverse causality. Conclusions: The study highlight the importance of screening and early prevention, contributing to a better understanding of osteoporosis epidemiology in Romania. Lifestyle habits significantly influence osteoporosis risk. Public health interventions focusing on prevention, education, and modifiable risk factors are essential for reducing the burden of osteoporosis.
References
1. Sølling AS, Langdahl BL, Cosman F. Recent advances in osteoporosis therapeutics. Annu Rev Med 2026; 77(1): 433-448.
2. Anam AK, Insogna K. Update on osteoporosis screening and management. Med Clin North Am 2021; 105(6): 1117-1134.
3. Sunyecz JA. The use of calcium and vitamin D in the management of osteoporosis. Ther Clin Risk Manag 2008; 4(4): 827-836.
4. De Martinis M, Sirufo MM, Polsinelli M, Placidi G, Di Silvestre D, Ginaldi L. Gender differences in osteoporosis: A single-center observational study. World J Mens Health 2021; 39(4): 750-759.
5. Ramachandran S, Williams SA, Weiss RJ, et al. Gender disparities in osteoporosis screening and management among older adults. Adv Ther 2021; 38(7): 3872-3887.
6. Gómez-de-Tejada Romero MJ, Navarro Rodríguez MD, Saavedra Santana P, Quesada Gómez JM, Jódar Gimeno E, Sosa Henríquez M. Prevalence of osteoporosis, vertebral fractures and hypovitaminosis D in postmenopausal women living in a rural environment. Maturitas 2014; 77(3): 282-286.
7. Zheng M, Wan Y, Liu G, et al. Differences in the prevalence and risk factors of osteoporosis in Chinese urban and rural regions: a cross-sectional study. BMC Musculoskelet Disord 2023; 24(1): 46.
8. Chiu CT, Lee JI, Lu CC, Huang SP, Chen SC, Geng JH. The association between body mass index and osteoporosis in a Taiwanese population: a cross-sectional and longitudinal study. Sci Rep 2024; 14(1): 8509.
9. Piñar-Gutierrez A, García-Fontana C, García-Fontana B, Muñoz-Torres M. Obesity and bone health: A complex relationship. Int J Mol Sci 2022; 23(15): 8303.
10. Kim J, Lee S, Kim SS. Association between body mass index and fragility fracture in postmenopausal women: a cross-sectional study using Korean National Health and Nutrition Examination Survey 2008-2009 (KNHANES IV). BMC Women’s Health 2021; 21: 60.
11. Lee J, Lee S, Jang S, Ryu OH. Age-related changes in the prevalence of osteoporosis according to gender and skeletal site: The Korea National Health and Nutrition Examination Survey 2008-2010. Endocrinol Metab 2011; 28(3): 180-191.
12. Almeida M. Aging mechanisms in bone. Bonekey Rep 2012; 1: 102.
13. Kanis JA, Johansson H, Oden A, et al. A. A family history of fracture and fracture risk: a meta-analysis. Bone 2004; 35(5): 1029-1037.
14. Percival MA, Anderson KB, Pasco JA, Hosking SM, Hyde NK. Parental fracture history is associated with offspring early-life fracture risk: The Geelong Osteoporosis Study. Bone 2025; 195: 117454.
15. Robitaille J, Yoon PW, Moore CA, et al. Prevalence, family history, and prevention of reported osteoporosis in U.S. women. Am J Prev Med 2008; 35(1): 47-54.
16. Gasparik A, Szőcs T, Pascanu I, Csata Z, Poiana C. Family history - BMD Independently - influences fracture risk. Acta Endocrinol (Bucharest) 2021; 17(4): 498-502.
17. Koromani F, Trajanoska K, Rivadeneira F, Oei L. Recent Advances in the Genetics of Fractures in Osteoporosis. Front Endocrinol (Lausanne) 2019; 10: 337.
18. Adejuyigbe B, Kallini J, Chiou D, Kallini JR. Osteoporosis: Molecular Pathology, Diagnostics, and Therapeutics. Int J Mol Sci 2023; 24(19): 14583.
19. Schembri M, Formosa MM. Identification of osteoporosis genes using family studies. Front Endocrinol (Lausanne) 2024; 15: 1455689.
20. Yong EL, Logan S. Menopausal osteoporosis: screening, prevention and treatment. Singapore Med J 2021; 62(4): 159-166.
21. Svejme O, Ahlborg H, Nilsson JÅ, Karlsson M. Early menopause and risk of osteoporosis, fracture and mortality: a 34-year prospective observational study in 390 women. BJOG 2012; 119(7): 810-816.
22. Anagnostis P, Siolos P, Gkekas NK, et al. Association between age at menopause and fracture risk: a systematic review and meta-analysis. Endocrine 2018; 63(2): 213-224.
23. Holvik K, Meyer HE, Laake I, Feskanich D, Omsland TK, Søgaard A-J. Milk drinking and risk of hip fracture: the Norwegian Epidemiologic Osteoporosis Studies (NOREPOS). Br J Nutr 2019; 121(6): 709-718.
24. Michaëlsson K, Wolk A, Lemming EW. Intake of milk or fermented milk combined with fruit and vegetable consumption in relation to hip fracture rates: a cohort study of Swedish women. J Bone Miner Res 2018; 33: 449-457.
25. Skuladottir SS, Hjaltadottir I, Launer LB. Milk intake and hip fracture incidence in community-dwelling old Icelandic adults. Osteoporos Int 2023; 34: 1951-1959.
26. Eysteinsdottir T, Halldorsson TI, Thorsdottir I, et al. Milk consumption throughout life and bone mineral content and density in elderly men and women. Osteoporos Int 2014; 25(2): 663-672.
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