• Luminita Smaranda IANCU “Grigore T. Popa” University of Medicine and Pharmacy Iasi


Even if the ASD etiopathogenesis is not completely elucidated, it is evident from the studies conducted so far that this disorder is not induced by the MMR vaccine and that the intervention of several cofactors (genetic, environmental and especially of the intestinal microbiome) is responsible for ASD installation, which affect more and more children during the last years. Until the future studies are to be completed, the gathered data regarding this mechanism, especially about the intestine - brain axis and gut microbiome, we can claim that MMR vaccination, represents the most redoubtable weapon of the humanity, meant to prevent and fight against a dangerous disease.


1. ***National Center of Infectious Control and Surveillance.
2. Wakefield AJ, Murch SH, Anthony A, Linnell J, Casson DM, Malik M, et al. Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children. Lancet 1998; 351: 637-41.
3. Taylor B et al: Autism and Measles, Mumps, and Rubella Vaccine: No Epidemiological Evidence for a Causal Association. Lancet. 1999; 12, 353 (9169):2026-9.
4. ***MMR Vaccine Does Not Cause Autism Examine the evidence! http://www.
5. Ursell LK, Metcalf JL, Parfrey LW, Knightn R. Defining the Human Microbiome. Nutr Rev 2012; 70 (Suppl 1): S38-S44.
6. Manimozhiyan A et all; Nature 2011; 473: 174-80. nature 09944# supplementary-information.
7. Simon Carding S, Kristin Verbeke K, Daniel T. Vipond, DT, Bernard M. Corfe BM, and Lauren J. Owen LJ. Dysbiosis of the gut microbiota in disease. Microb Ecol Health Dis 2015; 26: 10.3402/mehd.v26.26191.doi: 10.3402/mehd. v26.26191.
8. Pallavi Singh, et all. Intestinal microbial communities associated with acute enteric infections and disease recovery. Microbiome 2015; 3 (1) DOI: 10.1186/s40168-015-0109-2.
9. Rosenfeld CS. Microbiome Disturbances and Autism Spectrum Disorders. Drug Metab Dispos 2015; 43 (10): 1557-71.
10. Buie T. Potential Etiologic Factors of Microbiome Dusruption in Autism. Clin Therapeut 2005; 37, (5): 976 - 83.
11. Adams JB, Johansen LJ, Powell L, Quig D, Rubun A. Gastrointestinal flora and gastrointestinal status in children with autism-comparisons to typical children and correlation with autism severity. BMC Gastroenterol 2011; 11: 22. http://www.biomed
12. Parracho HM, Bungham M O, Gibson GR, McCartney A. Differences between the gut microflora of children with autistic spectrum disorders and that of healthy children. J Med Microbiol 2005; 54: 987-991. Downloaded from by
13. Luna RA et all, The Brain-Gut-Microbiome Axis: What Role Does It Play in Autism Spectrum Dis-order? Curr Dev Disord Rep 2016; 3 (1): 75-81. doi:10.1007/s40474-016-0077-7.
14. Rossignol DA, Genuis SJ, Frye RE. Environmental toxicants and autism spectrum disorders: a sys-tematic review. Translational Psychiatry 2014; 4, e360. doi:10.1038/ tp.2014.4.
15. Song YL, Liu C and Sydney M. Finegold SM. Real-Time PCR Quantitation of Clostridia in Feces of Autistic Children. Appl Environ Microbiol 2004; 70 (11): 6459-6465. doi: 10.1128/AEM.70.11.6459-6465.2004.
16. Sandler RH, Finegold SM, Bolte ER, et al. Short-term benefit from oral vancomycin treatment of regressive-onset autism. J Child Neurol 2000; 15: 429-435.
17. Mangiola F, Ianiro G, Franceschi F, Fagiuoli S, Gasbarrini G, Gasbarrini A. Gut microbiota in autism and mood disorders. World J Gastroenterol 2016; 22(1): 361-368. doi: 10.3748/wjg.v22.i1.361.
18. Curran EA, Dalman C, Kearney PM, et al. Association Between Obstetric Mode of Delivery and Autism Spectrum Disorder a Population-Based Sibling Design Study. JAMA Psychiatry 2015; 72 (9): 935-942. doi:10.1001/jamapsychiatry.2015.0846.
19. Posaria A, Viscontia P. Autism in 2016: the need for answers. J de Pediatria. 2017; 93 (2): 111-119.
20. Dickerson AS, Rahbar MH, Bakian AV et al. Autism spectrum disorder prevalence and associations with air concentrations of lead, mercury, and arsenic. Environ Monit Assess 2016; 188: 407. doi: 10.1007/s10661-016-5405-1.
21. Li Q, Ying Han Y, Dy ABC, Hagerman RJ. The Gut Microbiota and Autism Spectrum Disorders. Front Cell Neurosci 2017; 11: 120.doi: 10.3389/fncel.2017.00120).