CLINICAL CHANGES AND BIOMETRIC DIFFERENCES IN PATIENTS WITH PRIMARY OPEN ANGLE GLAUCOMA AND DIABETES
Aim of study was to emphasize the clinical changes and biometric alterations that appear in primary open angle glaucoma (POAG) patients if diabetes was associated. Material and methods: The study was designed in a cross-sectional manner, between 2015-2016 in the Ophthalmology Clinic of “Sf. Spiridon” County Clinical Emergency Hospital from Iasi. We included 87 eyes, from 87 patients, distributed in 4 groups: 24 patients - the control group (cataract), 26 patients - the type II diabetes group, 16 patients – POAG group, 21 patients - the combined disease group (POAG + diabetes). We recorded data related to the age of the patients (years), best corrected visual acuity (BCVA), intraocular pressure (IOP-mmHg), perimetry parameters (MD, PSD-dB), biometric parameters (axial lengths, anterior chamber depth, CDE - Cumulative Dissipated Energy, lens thickness). The duration of glaucoma/diabetes, the type and number of glaucoma medications were noted. Similarly, the duration of diabetes mellitus, glycemic value and glycosylated hemoglobin were recorded. Results: Mean age calculated for the control group was 72.33+/-11.26 years, 69.04+/-9.46 years for the DM group, 75.69+/-5.54 years for the POAG group and 59.95+/-3.89 years for the combined pathology. Secondly, we found the highest IOP in the POAG+DM group, compared with the rest of the study categories (20.33+/-2.3 mmHg in group IV vs. 18.19+/-4.3 mmHg in group III vs. 15.50+/1.9 mmHg vs. 14.21+/-2.68 mmHg in group I), p<0.05. We found statistically significant differences between the four groups in respect of lens size and the CDE mean values. Our data revealed that the smallest energy was used in group IV (CDE=8.5+/-1.77), compared to all the other categories: I (CDE=17.79+/-7.36, p = 0.000), II (CDE=18.15+/-11.74, p = 0.000), III (CDE=13.90+/-8.11, p = 0.000). Estimated lens volume in group IV was 4.85+/-0.17mm in POAG+DM patients, significantly larger than the rest of the groups (p<0.05) Conclusions: younger age, higher IOP, larger lens volume and lower CDE mean values were the parameters significantly different in POAG patients, if diabetes was associated.
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