CLINICAL AND EPIDEMIOLOGICAL ASPECTS OF GOUT, A DYSMETABOLIC DISABLING DISORDER
Abstract
Gout is a disease caused by disturbances of uric acid metabolism and it manifests as rheumatic pain with various clinical and developmental issues, but without any major diagnosis problems; it might unfavorably interfere with other metabolisms, especially with carbohydrate and lipid metabolism that interact and erode each other. Aims: To provide clinical and laboratory data and to follow the development of gout in patients treated in the clinic. Material and methods: The study included 28 patients (25 male and 3 female patients) diagnosed with gout, admitted to the First Clinic of Rheumatology of the Clinical Rehabilitation Hospital Iasi during 2012 - 2013. Results and discussion: A new diagnostic method, dual energy computed tomography, was effective in some selected cases of gout, as it may reveal uric acid crystals with specific densities in the damaged joints and periarticular soft tissues. Conclusions: Gout is a disorder that occurs when the uric acid produced by the body is stored in the form of crystals in joints and / or soft tissues. In joints, uric acid crystals precipitate and cause inflammatory arthritis that leads to swelling, redness, heat, pain and joint functional impotence.
References
2. Mikuls TR, McLean CH, Olivieri J. Quality of care indicators for gout management. Arthritis Rheum. 2004; 50: 937-943.
3. McCarty DJ, Hollander JL. Identification of urate crystals in gouty synovial fluid. Ann. Intern. Med. 1961; 54:452-460.
4. Roddy E, Zhang W, Doherty M. Concordance of the management of chronic gout in a UK primary-care population with the EULAR gout recommendations. Ann. Rheum. Dis. 2007; 66(10): 1311-1315.
5. Pascual E, Jovani V. Synovial fluid analysis. Best Pract. Res. Clin. Rheumatol. 2005; 19: 371-386.
6. Sivera F, Aragón R, Pascual E. First metatarsophalangeal joint aspiration using a 29-gauge needLe. Ann. Rheum. Dis. 2008; 67:273-275.
7. Thiele R, Schlesinger N. Diagnosis of gout by ultrasound. Rheumatol. 2007; 46(7): 1116-1121.
8. Jordan KM, Cameron JS, Snaith M. British Society for Rheumatology and British Health Professionals in Rheumatology Standards, Guidelines and Audit Working Group (SGAWG) British Society for Rheumatology and British Health Professionals in Rheumatology guideline for the management of gout. Rheumatol. 2007; 46: 1372-1374.
9. Keith MP, Gilliland WR. Updates in the management of gout. Am. J. Med. 2007; 120: 221-224.
10. Perez-Ruiz F, Liote F. Lowering serum uric acid levels: what is the optimal target for improving clinical outcomes in gout? Arthritis Rheum. 2007; 57: 1324-1328.
11. Shalom R, Rimbroth S, Rozenman D. Allopurinol-induced recurrent DRESS syndrome: pathophysi-ology and treatment. Ren. Fail. 2008; 30: 327-329.
12. Krishnan E, Baker JF, Furst DE. Gout and the risk of acute myocardial infarction. Arthrit Rheum. 2006; 54:2688-2696.
13. Săvoiu G, Drăgan S, Fira-Mladinescu I. et al. Corelaţii dintre grosimea intimă-medie la nivelul arterei carotide interne şi nivelele acidului uric seric la pacienţii hipertensivi. Rev Med Chir Soc Med Nat Iasi 2008; 112(4): 902-907.
14. Mitu F, Drăgan MV. Hiperuricemia şi sindromul metabolic, Rev Med Chir Med Nat Iasi. 2009; 113(4): 1001-1005.
15. Petriş A, Cimpoieşu D, Petriş, O, Costache I. Acidul uric, evenimentele cardio-vasculare şi disfuncţia renală-o legătură conjuncturală? Rev Med Chir Med Nat Iasi. 2012; 116(2): 407-412.
16. Barclay L, Vega C.Prospective study identifies weight gain and adiposity as possible risk factors for gout. Med News, 12 April 2005.
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