RED CELL DISTRIBUTION WIDTH (RDW) - A POTENTIAL PROGNOSIS FACTOR IN MALIGNANT MELANOMA
Although malignant melanoma accounts for less than 5% of all cancers, it is one of the most aggressive types of cancer, associated with a poor outcome. Survival rates significantly vary according to stage and even within the same stage there are significant survival differences. The aim of this study was to assess the role of red cell distribution width (RDW) as a potential prognosis factor for malignant melanoma. Also, this analysis aims to determine average survival and the time until relapse/progression of the disease in patients with malignant melanoma treated at the Regional Institute of Oncology Iasi (IRO) between 2013 and 2016. Materials and methods: We performed a retrospective analysis of melanoma patients treated in the IRO between 2013 and 2016. We collected several parameters including age, sex, tumor localization, clinical and pathological stage, Breslow Index, Clark level, ulceration and detailed therapeutic management. We then analyzed each parameter to assess its impact on progression-free survival and overall survival. Results: We identified RDW as a significant prognosis marker, with worse outcome for patients with abnormal RDW values. Additionally, tumor localization, Clark level, Breslow index and cancer stage also showed prognosis value. Conclusions: RDW is a useful, inexpensive prognosis marker that can better predict survival. Prospective studies are required for confirming the findings of the present analysis.
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