HISTOPATHOLOGICAL DIAGNOSIS CRITERIA IN ENDOMETRIAL HYPERPLASIA
Endometrial hyperplasia is a condition of the abnormal proliferative lesions of the endometrium. Aim: To highlight the value of histopathological examinations with assessment of the ways to obtain endometrial biopsies and the appreciation of the contribution of different histopathological techniques that can be used to establish a correct and complete diagnosis. Material and methods: The study was conducted in a group of 50 patients diagnosed with endometrial hyperplasia. In all cases the bioptic curettage was performed using a curette to obtain more abundant material for the histopathological examination. Results: Histopathological diagnosis guides the therapeutic attitude and has an important prognostic value. The study group was characterized by histoarchitectonic heterogeneity, presented even in the same case. Histoarchitectonic and cytological changes differentiate endometrial hyperplasia from physiological proliferative endometrium. Conclusions: The diagnosis of certainty between the four types of endometrial proliferation established by the WHO can only be done through the histopathological examination.
2. Simionescu C, Florescu M, Niculescu M, Bălă S, Manea M. Histopathologic aspects of the limited endometrial hyperplasias-a study concerning 149 cases. Romanian Journal of Morphology and Em-bryology 2005; 46(1): 51-55.
3. Yilmaz I, Baloglu H, Haholu A, Berber U, Yildirim S, Ergur AR. Objective risk definition for endo-metrial lesion spectrum: a diagnostic algorithm. Gynecol Oncol 2007; 105(2): 451-456.
4. Mazur MT. Endometrial hyperplasia/adenocarcinoma. a conventional approach. Ann Diagn Pathol. 2005; 9(3):174-181.
5. Sezgin M, Ismail AA., Histopathological challenges in the diagnosis of endometrial hyperplasia and carcinoma. Diagnostic Histopathology 2006; 12(5): 312-324.
6. Hammond R, Johnson J. Endometrial hyperplasia. Current Obstetrics & Gynaecology 2001; 11(3): 160-163.
7. Stolnicu S, Rădulescu D, Mocan S, Pantazescu A, Coroş M., The significance of morphologic and immunohistochemical patterns in the diagnosis of undifferentiated endometrial sarcoma. Rev Med Chir.2004; 108(4): 791-796.
8. Kojo R, Rawish MD, Mohamed M, Desouki MD, Oluwole Fadare MD. Atypical mucinous glandular proliferations in endometrial samplings: follow-up and other clinicopathological findings in 41 cases. Human Pathology 2017; 63: 53-62.
9. Kurman RJ, Kaminski PF, Norris HJ. The behavior of endometrial hyperplasia. A long-term study of "untreated" hyperplasia in 170 patients. Cancer. 1985; 56(2): 403-412.
10. Komm BS, Kharode YP, Bodine PV, Harris HA, Miller CP, Lyttle CR. Bazedoxifene acetate: a selec-tive estrogen receptor modulator with improved selectivity. Endocrinology 2005; 146(9): 3999-4008.
11. Trimble CL, Method M, Leitao M, Lu K, Ioffe O, Hampton M, Higgins R, Zaino R, Mutter GL. Management of endometrial precancers. Obstet. Gynecol 2012; 120: 1160-1175.
12. Tanner E, Puechl A, Levinson K, Havrilesky LJ, Sinno A, Secord AA, Fader AN, Lee PS. Use of a novel sentinel lymph node mapping algorithm reduces the need for pelvic lymphadenectomy in low-grade endometrial cancer. Gynecol. Oncol 2017; 147 (3): 535-540.
13. Gafton B, Porumb V, Ungurianu S, Marinca MV, Cocea C, Croitoru A, et al. Hepatocellular carcino-ma: insight in the biological treatment beyond sorafenib. Journal of BUON 2014; 19(4): 858-866.
14. Papadia A, Gasparri ML, Siegenthaler F, Imboden S, Mohr S, Mueller MD. FIGO stage IIIC endome-trial cancer identification among patients with complex atypical hyperplasia, grade 1 and 2 endometrioid endometrial cancer: laparoscopic indocy- anine green sentinel lymph node mapping versus frozen section of the uterus, why get around the problem? J. Cancer Res. Clin. Oncol. 2017;143 (3): 491-497.
15. Cobzeanu, MD, Costinescu, V, Rusu, CD, Mihailovici, S, Grigoras, M, Miron, L, Paduraru, D, Ara-ma, A. Laryngotracheal nonhodgkin's lymphoma. Chirurgia 2010; 105(1): 131-136.
Once an article is accepted for publication, MSJ requests a transfer of copyrights for published articles.
COPYRIGHT TRANSFER FORM FOR
REVISTA MEDICO-CHIRURGICALĂ A SOCIETĂȚII DE MEDICI ȘI NATURALIȘTI DIN IAȘI /
THE MEDICAL-SURGICAL JOURNAL OF THE SOCIETY OF PHYSICIANS AND NATURALISTS FROM IASI
We, the undersigned authors of the manuscript entitled
warrant that this manuscript, which is submitted for publication in the REVISTA MEDICO-CHIRURGICALĂ, has not been published and it is not under consideration for publication in another journal.
- we give the consent for publication in the REVISTA MEDICO-CHIRURGICALĂ, in printed and electronic format and we transfer unconditioned and complete the copyright of this manuscript to the REVISTA MEDICO-CHIRURGICALĂ, in the event of its acceptance.
- the manuscript does not break the intellectual property rights of any other person.
- we have read the submitted version of the manuscript and we are fully responsible for the content.
Names and signatures of authors / copyright owners (the following sequence is the authorship of the article):
N.B. All the authors must sign this form