• M. TUDOR “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Magdalena CUCIUREANU “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • Rodica CUCIUREANU “Grigore T. Popa” University of Medicine and Pharmacy Iasi
  • B.G. SLENCU “Grigore T. Popa” University of Medicine and Pharmacy Iasi


Ethephon (2-chloroethylphosphonic acid) is one of the most intensely used plant growth regulators. Aim: Assessment of hematological parameters during subacute intoxication with ethephon (200 mg/kg bw/day) in rats and evaluation of the potential protective effect of selenium (1 mg/kg bw/day) (administered as sodium selenite) in rats during the experimental intoxication by oral route with high doses of ethephon (200 mg/kg bw/day). Material and methods: Male Wistar rats were randomly assigned to four groups: Control group, Ethephon group (200 mg ethephon/kg bw/day, 14 days), Selenium group (1 mg Se/kg bw/day, 14 days), Selenium+ethephon group (200 mg ethephon/kg bw/day and 1 mg Se/kg bw/day). Blood samples were collected on the 15th day and a complete blood count was conducted by using an automated hematology analyzer. Results: Mean red blood cell count was 7.06x106/µl in the Ethephon group and 7.18x106/µl in the Selenium group, as compared to 7.16x106/µl in the Control group. Platelet count decreased from 1028.66x103/µl in the Control group to 999.66x103/µl in the Ethephon group. Total leukocyte count was 7.82x103/µl in the Ethephon group and 8.40x103/µl in the Selenium+ethephon group, as compared to a mean of 8.07x103/µl in the Control group. Conclusions: The modification of some of the hematological parameters in the groups to which ethephon was administered can be suggestive of the harmful effect of this substance (which is present as a residue in food products) on consumer health. Orally administered selenium (as sodium selenite) at a dose of 1 mg Se/kg bw, seems to have acted as a toxic and not as a protective agent during the intoxication with ethephon.

Author Biographies

M. TUDOR, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Faculty of Pharmacy
Department of Pharmaceutical Sciences (I)

Magdalena CUCIUREANU, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Faculty of Medicine
Department of Morpho-Functional Sciences (II)

Rodica CUCIUREANU, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Faculty of Pharmacy
Department of Pharmaceutical Sciences (I)

B.G. SLENCU, “Grigore T. Popa” University of Medicine and Pharmacy Iasi

Faculty of Pharmacy
Department of Pharmaceutical Sciences (I)


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